https://scholars.lib.ntu.edu.tw/handle/123456789/579246
Title: | Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease | Authors: | FENG-JUNG YANG Shu K.-H. Chen H.-Y. Chen I.-Y. Lay F.-Y. Chuang Y.-F. Wu C.-S. Tsai W.-C. Peng Y.-S. Hsu S.-P. CHIH-KANG CHIANG Wang G. Chiu Y.-L. |
Issue Date: | 2018 | Publisher: | BioMed Central Ltd. | Journal Volume: | 15 | Journal Issue: | 1 | Start page/Pages: | 15 | Source: | Immunity and Ageing | Abstract: | Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population. ? 2018 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049456407&doi=10.1186%2fs12979-018-0120-0&partnerID=40&md5=08db9a73978f307d08c10ea5e709b5d4 https://scholars.lib.ntu.edu.tw/handle/123456789/579246 |
ISSN: | 1742-4933 | DOI: | 10.1186/s12979-018-0120-0 | SDG/Keyword: | C reactive protein; calcium phosphate; CD45RA antigen; chemokine receptor CCR7; hemoglobin; immunoglobulin G antibody; adult; antibody titer; Article; atherosclerosis; CD4+ T lymphocyte; CD8+ T lymphocyte; comorbidity; controlled study; coronary artery disease; cytomegalovirus infection; diabetes mellitus; end stage renal disease; female; human; immunosenescence; inflammation; lymphocyte differentiation; major clinical study; male; monocyte; multivariate logistic regression analysis; prevalence; priority journal; sensitivity analysis; T lymphocyte subpopulation |
Appears in Collections: | 醫學系 |
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