https://scholars.lib.ntu.edu.tw/handle/123456789/579751
標題: | Apoptotic microparticles mediate the association between bisphenol A and subclinical atherosclerosis in a young population: A population-based study | 作者: | Chu, Pei-Lun Lin, Chien-Yu Sung, Fung-Chang TA-CHEN SU |
關鍵字: | Atherosclerosis; Bisphenol A (BPA); Carotid artery intima-media thickness (CIMT); Microparticle | 公開日期: | 18-八月-2021 | 卷: | 224 | 來源出版物: | Ecotoxicology and environmental safety | 摘要: | Bisphenol A (BPA) exposure is associated with atherosclerotic cardiovascular diseases. The interactions between BPA, extracellular microparticles (MPs), and atherosclerosis are unknown. A total of 103,756 young students participated in the mass urine-screening program in Taiwan between 1992 and 2000 were analyzed. After exclusion, 886 subjects were recruited to test the relationships between serum level of BPA, endothelial and platelet MPs as well as subclinical atherosclerosis represented by carotid artery intima-media thickness (CIMT). We found that an increment of one unit of log-BPA could lead to significant association between thicker CIMT and concentrations of endothelial microparticles and platelet microparticles in the cohort (odds ratio (OR) 1.23, P < 0.001). CD31 + /CD42a- (> 50%, OR 1.229, P = 0.001) and CD31 + /CD42a+ (≦ 50%, OR 1.262, P = 0.017 and > 50%, OR 1.212, P = 0.006) were significantly associated with thicker CIMT in the presence of elevated BPA. When considering the interactions between CD31 + /CD42a- and CD31 + /CD42a+ , we observed increased OR as CD31 + /CD42a- was greater than 50% (CD31 +/CD42a- > 50% and CD31 +/CD42a+ ≦ 50%, OR 1.356, P = 0.029; CD31 +/CD42a- > 50% and CD31 +/CD42a+ > 50%, OR 1.204, P = 0.014). Our study identified a higher risk of thicker CIMT associated with altered MPs in the presence of elevated BPA levels. BPA exposure is associated with endothelial dysfunction and subclinical atherosclerosis in a young population. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/579751 | ISSN: | 01476513 | DOI: | 10.1016/j.ecoenv.2021.112663 | SDG/關鍵字: | 4,4' isopropylidenediphenol; apoptosis regulatory protein; platelet endothelial cell adhesion molecule 1; protein CD42a; unclassified drug; apoptosis; cardiovascular disease; chemical compound; concentration (composition); pollution exposure; population dynamics; adolescent; adult; apoptosis; Article; atherosclerosis; blood level; carotid intima-media thickness; child; cohort analysis; controlled study; endothelial dysfunction; endothelial microparticle; environmental exposure; female; human; human cell; major clinical study; male; membrane microparticle; pathogenesis; platelet microparticle; protein protein interaction; risk factor; Taiwan; urinalysis; Taiwan |
顯示於: | 環境職業醫學科 |
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