https://scholars.lib.ntu.edu.tw/handle/123456789/579842
Title: | Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury | Authors: | LU-TING KUO Lu, Hsueh-Yi ABEL PO-HAO HUANG |
Keywords: | circadian rhythm; hypothermia; organ temperature; postoperative care; prognosis; traumatic brain injury;Circadian rhythm; Hypothermia; Organ temperature; Postoperative care; Prognosis; Traumatic brain injury | Issue Date: | 30-Jun-2021 | Journal Volume: | 11 | Journal Issue: | 7 | Source: | Journal of personalized medicine | Abstract: | Hypothermia has been used in postoperative management of traumatic brain injury (TBI); however, the rhythmic variation and prognostic value of brain temperature after TBI have never been studied. This study describes diurnal brain temperature patterns in comatose patients with TBI. Mesors of brain temperature, amplitude, and acrophase were estimated from recorded temperature measurements using cosinor analysis. The association of these patterns with clinical parameters, mortality, and functional outcomes in a 12-month follow-up was examined. According to the cosinor analysis, 59.3% of patients presented with circadian rhythms of brain temperature in the first 72 h postoperatively. The rhythm-adjusted mesor of brain temperature was 37.39 ± 1.21 °C, with a diminished mean amplitude of 0.28 (±0.25) °C; a shift of temperature acrophase was also observed. Multivariate logistic regression analysis revealed that initial Glasgow coma scale score, age, elevated blood glucose level, and circadian rhythm of brain temperature seemed to be predictive and prognostic factors of patients' functional outcomes. For the prediction of survival status, younger patients or those patients with mesor within the middle 50% of brain temperature were more likely to survive. The analysis of brain temperature rhythms in patients with moderate and severe TBI provided additional predictive information related to mortality and functional outcomes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/579842 | ISSN: | 2075-4426 | DOI: | 10.3390/jpm11070620 | SDG/Keyword: | dopamine; noradrenalin; adult; APACHE; Article; blood pressure; brain contusion; brain perfusion; brain temperature; cerebral perfusion pressure; circadian rhythm; clinical outcome; comatose patient; computer assisted tomography; craniectomy; craniotomy; decompressive craniectomy; diabetes mellitus; epidural hematoma; female; follow up; Glasgow coma scale; glucose blood level; human; hypertension; hypothermia; intracranial pressure; major clinical study; male; mean arterial pressure; middle aged; mortality; observational study; outcome assessment; oxygen saturation; postoperative care; prognosis; Rankin scale; resuscitation; subarachnoid hemorrhage; subdural hematoma; survival; systolic blood pressure; temperature measurement; traumatic brain injury |
Appears in Collections: | 醫學系 醫學系 |
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