https://scholars.lib.ntu.edu.tw/handle/123456789/581552
標題: | Synthesis of mof525/pedot composites as microelectrodes for electrochemical sensing of dopamine | 作者: | Chen S.S Han P.-C Kuok W.-K Lu J.-Y Gu Y Ahamad T Alshehri S.M Ayalew H Yu H.-H Wu K.C.-W. KEVIN CHIA-WEN WU |
關鍵字: | Amines; Ascorbic acid; Cost effectiveness; Electrocatalysis; Electrolytes; Electropolymerization; Metal-Organic Frameworks; Microelectrodes; Monomers; Morphology; Neurophysiology; Organometallics; Porphyrins; Probes; ELectrochemical detection; Electrochemical sensing; Electrolyte concentration; Electron transmission; In-vitro analysis; Poly(3 ,4 ethylenedioxythiophene) (PEDOT); Reactive surface area; Real time analysis; Chemical detection | 公開日期: | 2020 | 卷: | 12 | 期: | 9 | 起(迄)頁: | 1976117 | 來源出版物: | Polymers | 摘要: | Dopamine (DA) is an important neurotransmitter responsible for the functions and activities of multiple systems in human. Electrochemical detection of DA has the advantages of fast analysis and cost-effectiveness, while a regular electrode probe is restricted to laboratory use because the probe size is too large to be suitable for an in vivo or in vitro analysis. In this study, we have developed porphyrin-based metal organic framework (MOF525) and poly(3,4-ethylenedioxythiophene) (PEDOT)-based composites to modify microelectrode for DA detection. Two types of PEDOT monomers with different functional groups were investigated in this study. By varying the monomer ratios, electrolyte concentrations, and electropolymerization temperature, it was found that the PEDOT monomer containing carboxylic group facilitated the formation of regular morphology during the electropolymerization process. The uniform morphology of the PEDOT promoted the electron transmission efficiency in the same direction, while the MOF525 provided a large reactive surface area for electrocatalysis of DA. Thus, the MOF525/PEDOT composite improved the sensitivity-to-noise ratio of DA signaling, where the sensitivity reached 11 nA/?M in a good linear range of 4–100 ?M. In addition, porphyrin-based MOF could also increase the selectivity to DA against other common clinical interferences, such as ascorbic acid and uric acid. The as-synthesized microelectrode modified with MOF525/PEDOT in this study exhibited great potential in real time analysis. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093935817&doi=10.3390%2fpolym12091976&partnerID=40&md5=bea9ac9773d41a5bbccc8f47e58cddb2 https://scholars.lib.ntu.edu.tw/handle/123456789/581552 |
ISSN: | 20734360 | DOI: | 10.3390/polym12091976 |
顯示於: | 化學工程學系 |
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