https://scholars.lib.ntu.edu.tw/handle/123456789/582182
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tong M.J. | en_US |
dc.contributor.author | Blatt L.M. | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.contributor.author | Cheng J.T. | en_US |
dc.contributor.author | Corey W.G. | en_US |
dc.date.accessioned | 2021-09-04T06:18:56Z | - |
dc.date.available | 2021-09-04T06:18:56Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751299464&doi=10.3748%2fwjg.v12.i41.6620&partnerID=40&md5=053cfdf1da97c7c70b1bf4702615842b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/582182 | - |
dc.description.abstract | Aim: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma. Methods: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. Results: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1-16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.021 and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to henatocellular carcinoma. Conclusion: Our results show that high levels of baseline serum HBV DNA are associated with non-hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. ? 2006 The WJG Press. All rights reserved. | - |
dc.publisher | Baishideng Publishing Group Co | - |
dc.relation.ispartof | World Journal of Gastroenterology | - |
dc.subject | Basal core promoter mutants; Hepatitis B e antigen; Hepatitis B viral DNA; Hepatitis B viral genotypes; Hepatocellular carcinoma; Liver failure; Precore mutants | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alpha fetoprotein; hepatitis B(e) antibody; hepatitis B(e) antigen; virus DNA; adult; age; article; Asian; computer assisted tomography; controlled study; death; disease association; disease course; echography; esophagus varices bleeding; female; follow up; gene mutation; genotype; hepatitis B; Hepatitis B virus; human; liver biopsy; liver cell carcinoma; liver failure; logistic regression analysis; major clinical study; male; multivariate analysis; nuclear magnetic resonance imaging; nucleotide sequence; prediction; promoter region; race difference; real time polymerase chain reaction; sepsis; sex ratio; univariate analysis; virus mutant | - |
dc.title | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3748/wjg.v12.i41.6620 | - |
dc.identifier.pmid | 17075974 | - |
dc.identifier.scopus | 2-s2.0-33751299464 | - |
dc.relation.pages | 6620-6626 | - |
dc.relation.journalvolume | 12 | - |
dc.relation.journalissue | 41 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床醫學研究所 |
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