Diffuse midline glioma presenting with central sleep apnea and pulmonary hypertension in a 4-year-old patient: A case report

Abstract

Central sleep apnea is a rare disorder in the pediatric population with various initial presentations and is secondary to many underlying diseases.We report on a 4-year-old boy with episodes of syncope. He also had pulmonary hypertension and cardiomegaly. Polysomnography showed the finding for central sleep apnea with a high apnea-hypopnea index (up to 138.1 events/h). Brain magnetic resonance imaging showed an ill-defined area near the medulla oblongata and lower pons. The lesion fromabrainstembiopsy confirmed the diagnosis of low-grade glioma. Conservativemedical follow-up was suggested, and brainmagnetic resonance imaging 6months later showed no obvious tumor progression. To our best knowledge, this is the first case report that workup on the cause of syncope and pulmonary hypertension led to the final diagnosis of central sleep apnea and a brain neoplasm.