https://scholars.lib.ntu.edu.tw/handle/123456789/582864
Title: | Imaging of Cancer Cells and Dictated Cytotoxicity Using Aptamer-Guided Hybridization Chain Reaction (HCR)-Generated G-Quadruplex Chains | Authors: | Jou, Amily Fang Ju Chou, Yi Te Willner, Itamar JA-AN ANNIE HO |
Keywords: | DNA nanotechnology | G-Quadruplex | hybridization chain reaction (HCR) | photodynamic therapy | theranostic;DNA nanotechnology; G-Quadruplex; hybridization chain reaction (HCR); photodynamic therapy; theranostic | Issue Date: | 1-Jan-2021 | Publisher: | John Wiley and Sons Inc | Journal Volume: | 60 | Journal Issue: | 40 | Start page/Pages: | 21673-21678 | Source: | Angewandte Chemie - International Edition | Abstract: | DNA nanotechnology provides powerful tools for developing cancer theranostics. Here we introduce the autonomous surface-nucleolin-guided HCR that leads to the polymerization of G-quadruplex polymer chains, in which the ZnII-protoporphyrin IX is intercalated. We demonstrate that MDA-MB-231 (Triple Negative Breast Cancer cells, TNBC) with overexpressed surface nucleolin were able to induce HCR leading to the formation of the ZnIIPPIX-loaded G-quadruplex polymer chains, while the M10 epithelial breast cells served as control. The ZnIIPPIX-loaded nanowires allow the selective imaging of TNBC, and their permeation into the TNBC leads to selective cytotoxicity and guided photodynamic therapy toward the cancer cells due to structural perturbation of the membranes. The aptamer-guided HCR-generated G-quadruplex polymer chains may serve as a versatile tool to target TNBC featuring poor prognosis and high pathological risk of recurrence, thus offering a promising theranostic platform. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/582864 | ISSN: | 14337851 | DOI: | 10.1002/anie.202106147 | SDG/Keyword: | Automatic guided vehicles; Cytology; Diseases; Photodynamic therapy; Theranostics; DNA nanotechnology; G-quadruplexes; Hybridization chain reactions; Protoporphyrin IX; Selective imaging; Structural perturbation; Triple-negative breast cancers; Versatile |
Appears in Collections: | 生化科技學系 |
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