https://scholars.lib.ntu.edu.tw/handle/123456789/583340
標題: | Norepinephrine Administration Is Associated with Higher Mortality in Dialysis Requiring Acute Kidney Injury Patients with Septic Shock | 作者: | Chen, Ying-Ying VIN-CENT WU Huang, Wei-Chieh YU-CHANG YEH Wu, Mai-Szu Huang, Chiu-Ching KWAN-DUN WU Fang, Ji-Tseng Wu, Chih-Jen TAI-SHUAN LAI YU-FENG LIN I-JUNG TSAI CHUN-FU LAI TAO-MIN HUANG TZONG-SHINN CHU YUNG-MING CHEN Chang, Yu-Hsing Lai, Chien-Heng Tseng, Li-Jung Wang, Jian-Jhong Chen, Cheng-Yi Shiao, Chih-Chung Wang, Wei-Jie Lin, Jui-Hsiang Wu, Che-Hsiung Wu, Chih-Jen Lu, Kuo-Cheng Kan, Wei-Chih Huang, Chiu-Ching Chou, Che-Yi Yang, Ya-Fei Tsai, Jen-Pi Hu, Fu-Chang Lee, Chien-Te Chen, Jin-Bor Lee, Chih-Hsiung Lee, Wen-Chin Li, Lung-Chih Chen, Te-Chuan Lin, Hugo You-Hsien Chen, Yung-Chang Lee, Chin-Chan Sun, Chiao-Yin Pan, Heng-Chih Chang, Ming-Yang Jenq, Chang-Chyi Lin, Chan-Yu Chang, Chih-Hsiang Tsai, Tsung-Yu Chen, Cheng-Min Lin, En-Tzu Lin, Cheng-Jua Wu, Pei-Chen Kuo, Feng-Chi Weng, Chih-Jen Chen, Li-Kwang SHUEI-LIONG LIN WEI-SHUN YANG Hsu, Wen-Ding Leu, Jyh-Gang Chang, Jui-Ting Liou, Hung-Hsiang Hsu, Kuo-Hsiung Wu, Ming-Ju Huang, Chun-Te You, Zi-Hong Chang, Chao-Fu Chen, Tzen-Wen Chen, Hsi-Hsien FAN-CHI CHANG Lin, Yen-Chung Wu, Mai-Szu Kao, Chih-Chin Hung, Szu-Chun Kuo, Ko-Lin Wu, Che-Hsiung Tarng, Der-Cherng Chen, Jinn-Yang Yang, Chih-Yu Lee, Kuo-Hua Ko, Sheng-Wen The NSARF, CAKS Group |
關鍵字: | acute kidney injury; critical care; dialysis; norepinephrine; sepsis; vasoactive agents;Acute kidney injury; Critical care; Dialysis; Norepinephrine; Sepsis; Vasoactive agents | 公開日期: | 12-九月-2018 | 卷: | 7 | 期: | 9 | 來源出版物: | Journal of clinical medicine | 摘要: | (1) Background: Norepinephrine (NE) is the first-line vasoactive agent used in septic shock patients; however, the effect of norepinephrine on dialysis-required septic acute kidney injury (AKI-D) patients is uncertain. (2) Methods: To evaluate the impact of NE on 90-day mortality and renal recovery in septic AKI-D patients, we enrolled patients in intensive care units from 30 hospitals in Taiwan. (3) Results: 372 patients were enrolled and were divided into norepinephrine users and non-users. After adjustment by Inverse probability of treatment weighted (IPTW), there was no significant difference of baseline comorbidities between the two groups. NE users had significantly higher 90-day mortality rate and using NE is a strong predictor of 90-day mortality in the multivariate Cox regression (HR = 1.497, p = 0.027) after adjustment. The generalized additive model disclosed norepinephrine alone exerted a dose⁻dependent effect on 90-day mortality, while other vasoactive agents were not. (4) Conclusion: Using norepinephrine in septic AKI-D patients is associated with higher 90-day mortality and the effect is dose-dependent. Further study to explore the potential mechanism is needed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/583340 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm7090274 | SDG/關鍵字: | noradrenalin; acute kidney failure; adult; aged; APACHE; Article; cohort analysis; comorbidity assessment; continuous renal replacement therapy; creatinine blood level; disease severity; female; fluid resuscitation; geographic distribution; Glasgow coma scale; heart failure; heart output; hemodialysis; hepatorenal syndrome; hospital discharge; human; intensive care unit; international normalized ratio; major clinical study; male; mean arterial pressure; middle aged; mortality rate; observational study; prospective study; renal replacement therapy; respiratory failure; septic shock; Sequential Organ Failure Assessment Score; urea nitrogen blood level |
顯示於: | 醫學系 |
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