https://scholars.lib.ntu.edu.tw/handle/123456789/584481
標題: | Alzheimer's disease is associated with prostate cancer: A population-based study | 作者: | Lin H.-C. Kao L.-T. Chung S.-D. Huang C.-C. Shia B.-C. CHAO-YUAN HUANG |
關鍵字: | Alzheimer's disease; Epidemiology; Prostate cancer | 公開日期: | 2018 | 出版社: | Impact Journals LLC | 卷: | 9 | 期: | 7 | 起(迄)頁: | 7616-7622 | 來源出版物: | Oncotarget | 摘要: | Alzheimer's disease and cancer are increasingly prevalent with advancing age. However, the association between Alzheimer's disease and prostate cancer remains unclear. The aim of this study was to examine the relationship between prior Alzheimer's disease and subsequent prostate cancer using a population-based dataset in Taiwan. Data for this study were sourced from the Taiwan Longitudinal Health Insurance Database 2005. This case-control study included 2101 prostate cancer patients as cases and 6303 matched controls. We used conditional logistic regression analyses to calculate the odds ratio (OR) and corresponding 95% confidence interval (CI) for Alzheimer's disease between prostate cancer patients and controls. We found that of the 8404 sampled patients, 128 (1.5%) had been diagnosed with Alzheimer's disease prior to the index date. A Chi-squared test showed that there was a significant difference in the prevalences of prior Alzheimer's disease between prostate cancer patients and controls (2.1% vs. 1.3%, p < 0.001). The conditional logistic regression analysis showed that the OR of prior Alzheimer's disease for prostate cancer patients was 1.53 (95% CI: 1.06~2.21) compared to controls. Furthermore, the OR of prior Alzheimer's disease for prostate cancer patients was 1.52 (95% CI: 1.04~2.22) compared to controls after adjusting for hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity, prostatitis, gonorrhea or chlamydia infection, testitis or epididymitis, and alcohol abuse/alcohol dependency syndrome. This study revealed an association between prior Alzheimer's disease and prostate cancer. We suggest that clinicians be alert to the increased risk of prostate cancer when caring for elderly individuals with Alzheimer's disease. ? Lin et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040981702&doi=10.18632%2foncotarget.24139&partnerID=40&md5=1ba153b4662e36e2c3dbfdc8838dd0f3 https://scholars.lib.ntu.edu.tw/handle/123456789/584481 |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.24139 | SDG/關鍵字: | aged; alcohol abuse; alcoholism; Alzheimer disease; ambulatory care; Article; cancer risk; case control study; chlamydiasis; controlled study; diabetes mellitus; disease association; epididymitis; gonorrhea; health care utilization; human; hyperlipidemia; hypertension; ischemic heart disease; major clinical study; male; obesity; orchitis; population based case control study; prevalence; prostate cancer; prostatitis; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。