https://scholars.lib.ntu.edu.tw/handle/123456789/584532
標題: | A population-based study on the association between benign prostatic enlargement and rheumatoid arthritis | 作者: | Tzeng Y.-M. Kao L.-T. Lin H.-C. CHAO-YUAN HUANG Thumbikat P. |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 7 | 起(迄)頁: | e0133013 | 來源出版物: | PLoS ONE | 摘要: | Benign prostatic hyperplasia is one of the chronic inflammatory conditions in ageing male populations. Rheumatoid arthritis (RA) is a major autoimmune disease and is also regarded as a chronic inflammatory disorder. Although RA and benign prostatic enlargement (BPE) may share the same underlying etiologies, almost no study has ever attempted to explore the relationship between RA and BPE. The aim of this study was to explore the relationship between RA and BPE using a population-based dataset. This case-control study used data retrieved from the Taiwan Longitudinal Health Insurance Database 2005. This study comprised 18,716 patients with BPE and 18,716 age-matched patients without BPE. Conditional logistic regression analyses were performed to calculate the odds ratio (OR) for having been previously diagnosed with RA between patients with BPE and comparison patients. In total, 485 of the 37,432 sampled patients (1.3%) had received a prior RA diagnosis. There was a significant difference in the prevalence of prior RA between cases and controls (1.6% vs. 1.0%, p<0.001). After adjusting for patient's urbanization level, monthly income, geographic region, and obesity, the adjusted OR was 1.54 (95% CI = 1.28?1.85) for patients with BPE compared to comparison patients. In addition, the sensitivity analysis showed that BPE was consistently and significantly associated with a prior RA diagnosis even after excluding subjects diagnosed with RA within 1, 2, or 3 years prior to the index date (the adjusted ORs were 1.46, 1.50, and 1.42, respectively). We concluded that there was a significant association between prior RA and BPE. Further large-scale longitudinal studies are suggested to clarify the causal relationship between RA and BPE. ? 2015 Tzeng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940488354&doi=10.1371%2fjournal.pone.0133013&partnerID=40&md5=2de16be3c6a31cde4f3fd6cd929d391d https://scholars.lib.ntu.edu.tw/handle/123456789/584532 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0133013 | SDG/關鍵字: | adult; Article; biogeographic region; controlled study; disease association; human; income; major clinical study; male; obesity; onset age; population based case control study; prevalence; prostate hypertrophy; rheumatoid arthritis; urbanization; case control study; factual database; middle aged; odds ratio; pathology; prostate hypertrophy; rheumatoid arthritis; risk factor; socioeconomics; Taiwan; Arthritis, Rheumatoid; Case-Control Studies; Databases, Factual; Humans; Male; Middle Aged; Odds Ratio; Prevalence; Prostatic Hyperplasia; Risk Factors; Socioeconomic Factors; Taiwan |
顯示於: | 醫學系 |
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