https://scholars.lib.ntu.edu.tw/handle/123456789/584897
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JULIA YU-FONG CHANG | en_US |
dc.contributor.author | Lin M.-C. | en_US |
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.date.accessioned | 2021-10-15T08:26:52Z | - |
dc.date.available | 2021-10-15T08:26:52Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0002-9173 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345258410&doi=10.1309%2fC5P6NUQ2NW6LCTBP&partnerID=40&md5=013d3c57f1e3301e0b76ef8902e8e7f2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/584897 | - |
dc.description.abstract | To evaluate the etiologic role of human papillomavirus (HPV) in oral carcinogenesis, DNA samples were purified from 103 oral squamous cell carcinoma (OSCC) and 30 normal oral mucosal (NOM) specimens. A nested polymerase chain reaction, DNA sequencing, and gene-chip HPV typing were used to identify multiple HPV types in our samples. We found that the positive rates of all HPV types and of high-risk HPV types were significantly higher in OSCC samples (49.5% and 41.7%, respectively) than in NOM samples (6/30 [20%; P < .01] and 5/30 [17%; P < .05], respectively) and significantly higher in non-oral habits (OH)-associated OSCC samples (31/51 [61%] and 28/51 [55%], respectively) than in OH-associated OSCC samples (20/52 [38%; P < .05] and 15/52 [29%; P < .001], respectively). High-risk HPV types and all HPV types had odds ratios of 3.97 (P = .0097) and 3.92 (P = .006), respectively. Our results suggest that HPVs, particularly high-risk HPVs, might be associated with the development of OSCCs, especially the non-OH-associated OSCCs. | en_US |
dc.publisher | American Society of Clinical Pathologists | en_US |
dc.relation.ispartof | American Journal of Clinical Pathology | en_US |
dc.subject | High-risk HPV types; HPV; Human papillomavirus; Oral cancer | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | DNA; adult; aged; article; carcinogenesis; controlled study; DNA sequence; female; human; human tissue; major clinical study; male; mouth carcinoma; mouth mucosa; nonhuman; Papilloma virus; polymerase chain reaction; priority journal; virus identification; virus typing | - |
dc.title | High-Risk Human Papillomaviruses May Have an Important Role in Non-Oral Habits-Associated Oral Squamous Cell Carcinomas in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1309/C5P6NUQ2NW6LCTBP | - |
dc.identifier.pmid | 14671980 | - |
dc.identifier.scopus | 2-s2.0-0345258410 | - |
dc.relation.pages | 909-916 | en_US |
dc.relation.journalvolume | 120 | en_US |
dc.relation.journalissue | 6 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.orcid | 0000-0002-3880-3787 | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 牙醫學系 |
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