https://scholars.lib.ntu.edu.tw/handle/123456789/584897
標題: | High-Risk Human Papillomaviruses May Have an Important Role in Non-Oral Habits-Associated Oral Squamous Cell Carcinomas in Taiwan | 作者: | JULIA YU-FONG CHANG Lin M.-C. CHUN-PIN CHIANG |
關鍵字: | High-risk HPV types; HPV; Human papillomavirus; Oral cancer | 公開日期: | 2003 | 出版社: | American Society of Clinical Pathologists | 卷: | 120 | 期: | 6 | 起(迄)頁: | 909-916 | 來源出版物: | American Journal of Clinical Pathology | 摘要: | To evaluate the etiologic role of human papillomavirus (HPV) in oral carcinogenesis, DNA samples were purified from 103 oral squamous cell carcinoma (OSCC) and 30 normal oral mucosal (NOM) specimens. A nested polymerase chain reaction, DNA sequencing, and gene-chip HPV typing were used to identify multiple HPV types in our samples. We found that the positive rates of all HPV types and of high-risk HPV types were significantly higher in OSCC samples (49.5% and 41.7%, respectively) than in NOM samples (6/30 [20%; P < .01] and 5/30 [17%; P < .05], respectively) and significantly higher in non-oral habits (OH)-associated OSCC samples (31/51 [61%] and 28/51 [55%], respectively) than in OH-associated OSCC samples (20/52 [38%; P < .05] and 15/52 [29%; P < .001], respectively). High-risk HPV types and all HPV types had odds ratios of 3.97 (P = .0097) and 3.92 (P = .006), respectively. Our results suggest that HPVs, particularly high-risk HPVs, might be associated with the development of OSCCs, especially the non-OH-associated OSCCs. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345258410&doi=10.1309%2fC5P6NUQ2NW6LCTBP&partnerID=40&md5=013d3c57f1e3301e0b76ef8902e8e7f2 https://scholars.lib.ntu.edu.tw/handle/123456789/584897 |
ISSN: | 0002-9173 | DOI: | 10.1309/C5P6NUQ2NW6LCTBP | SDG/關鍵字: | DNA; adult; aged; article; carcinogenesis; controlled study; DNA sequence; female; human; human tissue; major clinical study; male; mouth carcinoma; mouth mucosa; nonhuman; Papilloma virus; polymerase chain reaction; priority journal; virus identification; virus typing |
顯示於: | 牙醫學系 |
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