https://scholars.lib.ntu.edu.tw/handle/123456789/585403
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang H.-C. | en_US |
dc.contributor.author | Chen I.-C. | en_US |
dc.contributor.author | Tsay Y.-C. | en_US |
dc.contributor.author | Li Z.-R. | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.contributor.author | HAI-GWO HWU | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.date.accessioned | 2021-10-22T07:39:44Z | - |
dc.date.available | 2021-10-22T07:39:44Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 20452322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019620893&doi=10.1038%2fs41598-017-01791-4&partnerID=40&md5=d058bda4ae8f3d51cf420f4a929ced5a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/585403 | - |
dc.description.abstract | Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously characterize alcoholism susceptibility and onset age in 65 independent non-Hispanic Caucasian males in the Collaborative Study on the Genetics of Alcoholism. Following data quality control, we analysed 22 single nucleotide polymorphisms (SNPs) on 12 candidate genes. The single-SNP analysis showed that the dominant minor allele of rs2134655 on DRD3 increases alcoholism susceptibility; the dominant minor allele of rs1439047 on NTRK2 delays the alcoholism onset age, but the additive minor allele of rs172677 on GRIN2B and the dominant minor allele of rs63319 on ALDH1A1 advance the alcoholism onset age; and the dominant minor allele of rs1079597 on DRD2 shortens the onset age range. Similarly, multiple-SNPs analysis revealed joint effects of rs2134655, rs172677 and rs1079597, with an adjustment for habitual smoking. This study provides a more comprehensive understanding of the genetics of alcoholism than previous case-control studies. ? 2017 The Author(s). | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | transcriptome; alcoholism; allele; case control study; female; gene expression profiling; gene frequency; gene linkage disequilibrium; genetic association study; genetic predisposition; genetics; haplotype; human; Kaplan Meier method; male; single nucleotide polymorphism; Alcoholism; Alleles; Case-Control Studies; Female; Gene Expression Profiling; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Kaplan-Meier Estimate; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Transcriptome | - |
dc.title | Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-017-01791-4 | - |
dc.identifier.pmid | 28512340 | - |
dc.identifier.scopus | 2-s2.0-85019620893 | - |
dc.relation.pages | 1975 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.orcid | 0000-0002-2582-2807 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。