https://scholars.lib.ntu.edu.tw/handle/123456789/585427
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, C.-H. | en_US |
dc.contributor.author | TZUNG-JENG HWANG | en_US |
dc.contributor.author | Chen, P.-J. | en_US |
dc.contributor.author | Chou, T.-L. | en_US |
dc.contributor.author | Hsu, Y.-C. | en_US |
dc.contributor.author | CHIH-MIN LIU | en_US |
dc.contributor.author | Wang, H.-L. | en_US |
dc.contributor.author | Chen, C.-M. | en_US |
dc.contributor.author | Hua, M.-S. | en_US |
dc.contributor.author | HAI-GWO HWU | en_US |
dc.contributor.author | CHUNG-MING CHEN | en_US |
dc.date.accessioned | 2021-10-22T07:39:52Z | - |
dc.date.available | 2021-10-22T07:39:52Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 9254927 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935446045&doi=10.1016%2fj.pscychresns.2014.08.010&partnerID=40&md5=26c85046dddd43c3ca4390538b5233be | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/585427 | - |
dc.description.abstract | Recent studies suggest that structural and functional alterations of the language network are associated with auditory verbal hallucinations (AVHs) in schizophrenia. However, the ways in which the underlying structure and function of the network are altered and how these alterations are related to each other remain unclear. To elucidate this, we used diffusion spectrum imaging (DSI) to reconstruct the dorsal and ventral pathways and employed functional magnetic resonance imaging (fMRI) in a semantic task to obtain information about the functional activation in the corresponding regions in 18 patients with schizophrenia and 18 matched controls. The results demonstrated decreased structural integrity in the left ventral, right ventral and right dorsal tracts, and decreased functional lateralization of the dorsal pathway in schizophrenia. There was a positive correlation between the microstructural integrity of the right dorsal pathway and the functional lateralization of the dorsal pathway in patients with schizophrenia. Additionally, both functional lateralization of the dorsal pathway and microstructural integrity of the right dorsal pathway were negatively correlated with the scores of the delusion/hallucination symptom dimension. Our results suggest that impaired structural integrity of the right dorsal pathway is related to the reduction of functional lateralization of the dorsal pathway, and these alterations may aggravate AVHs in schizophrenia. ? 2014 Elsevier Ireland Ltd. All rights reserved. | - |
dc.relation.ispartof | Psychiatry Research - Neuroimaging | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; Article; auditory hallucination; auditory lateralization; brain region; clinical article; controlled study; delusion; diffusion spectrum imaging; disease exacerbation; dorsal language pathway; female; functional magnetic resonance imaging; human; image reconstruction; male; nerve cell network; nuclear magnetic resonance scanner; priority journal; schizophrenia; semantics; three dimensional imaging; tractography; brain; diffusion weighted imaging; functional neuroimaging; hallucination; hemispheric dominance; language; nerve tract; nuclear magnetic resonance imaging; pathology; pathophysiology; physiology; procedures; Adult; Cerebrum; Diffusion Magnetic Resonance Imaging; Female; Functional Laterality; Functional Neuroimaging; Hallucinations; Humans; Language; Magnetic Resonance Imaging; Male; Neural Pathways; Schizophrenia | - |
dc.title | Reduced structural integrity and functional lateralization of the dorsal language pathway correlate with hallucinations in schizophrenia: A combined diffusion spectrum imaging and functional magnetic resonance imaging study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.pscychresns.2014.08.010 | - |
dc.identifier.pmid | 25241043 | - |
dc.identifier.scopus | 2-s2.0-84935446045 | - |
dc.relation.pages | 303-310 | - |
dc.relation.journalvolume | 224 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Center for Integrated Dementia Care | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.orcid | 0000-0001-7894-9484 | - |
crisitem.author.orcid | 0000-0001-7016-8990 | - |
crisitem.author.orcid | 0000-0002-2582-2807 | - |
crisitem.author.orcid | 0000-0002-0023-5817 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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