https://scholars.lib.ntu.edu.tw/handle/123456789/586665
標題: | Probiotic Lactobacillus spp. act Against Helicobacter pylori-induced Inflammation | 作者: | Chen, Yi-Hsing Tsai, Wan-Hua Wu, Hui-Yu Chen, Chun-Ya Yeh, Wen-Ling Chen, Ya-Hui Hsu, Hui-Ying Chen, Wei-Wei Chen, Yu-Wen Chang, Wen-Wei Lin, Tzu-Lung HSIN-CHIH LAI Lin, Yu-Hsin Lai, Chih-Ho |
關鍵字: | Helicobacter pylori; Lactobacillus; inflammation; probiotic | 公開日期: | 14-一月-2019 | 卷: | 8 | 期: | 1 | 來源出版物: | Journal of clinical medicine | 摘要: | The bacterial species, Helicobacter pylori, is associated with several gastrointestinal diseases, and poses serious health threats owing to its resistance to antibiotics. Lactobacillus spp., on the other hand, possess probiotic activities that have beneficial effects in humans. However, the mechanisms by which Lactobacillus spp. harbor favorable functions and act against H. pylori infection remain to be explored. The aim of this study was to investigate the ability of bacterial strains, Lactobacillus rhamnosus and Lactobacillus acidophilus, termed GMNL-74 and GMNL-185, respectively, to inhibit H. pylori growth and inflammation. Our results showed that GMNL-74 and GMNL-185 possess potent antimicrobial activity against multidrug resistant (MDR)-H. pylori. In addition, an in vitro cell-based model revealed that the inhibition of H. pylori adhesion and invasion of gastric epithelial cells and interleukin-8 production were significantly decreased by treatment with both the Lactobacillus strains. In vivo studies demonstrated that colonization of H. pylori and induced inflammation in the mouse stomach were also alleviated by these Lactobacillus strains. Furthermore, the abundance of beneficial gut bacteria, including Bifidobacterium spp. and Akkermansia muciniphilia, were significantly increased in H. pylori-infected mice treated with GMNL-74 and GMNL-185. These results demonstrate that Lactobacillus spp. ameliorate H. pylori-induced inflammation and supports beneficial gut specific bacteria that act against H. pylori infection. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/586665 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm8010090 |
顯示於: | 醫學檢驗暨生物技術學系 |
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