https://scholars.lib.ntu.edu.tw/handle/123456789/588820
Title: | Increasing incidence of recent hepatitis D virus infection in HIV-infected patients in an area hyperendemic for hepatitis B virus infection | Authors: | CHIEN-CHING HUNG Wu S.-M. Lin P.-H. WANG-HUEI SHENG Yang Z.-Y. HSIN-YUN SUN Tsai M.-S. Lee K.-Y. Huang M.-S. Chang S.-F. Su Y.-C. Liu W.-C. SUI-YUAN CHANG |
Issue Date: | 2014 | Publisher: | Oxford University Press | Journal Volume: | 58 | Journal Issue: | 11 | Start page/Pages: | 1625-1633 | Source: | Clinical Infectious Diseases | Abstract: | Background: Superinfection with hepatitis D virus (HDV) may increase the risk for hepatitis flares and chronic hepatic complications in patients with chronic hepatitis B virus (HBV) infection. This retrospective observational study aimed to examine the incidence of and factors associated with recent HDV superinfection among individuals coinfected with human immunodeficiency virus (HIV) and HBV. Method: Anti-HDV immunoglobulin G (IgG) was sequentially determined in 375 HIV/HBV-coinfected patients to estimate the HDV incidence between 1992 and 2012. Plasma HDV and HBV loads and HBV surface antigen (HBsAg) levels were determined for the HDV seroconverters. A nested case-control study was conducted to identify the associated factors with HDV seroconversion. Phylogenetic analysis was performed using HDV sequences amplified from HDV seroconverters and HDV-seropositive patients at baseline. Results: During 1762.4 person-years of follow-up [PYFU], 16 patients seroconverted for HDV, with an overall incidence rate of 9.07 per 1000 PYFU, which increased from 0 in 1992-2001, to 3.91 in 2002-2006, to 13.26 per 1000 PYFU in 2007-2012 (P < .05). Recent HDV infection was associated with elevated aminotransferase and bilirubin levels and elevated rapid plasma reagin titers. Of the 12 patients with HDV viremia, 2 were infected with genotype 2 and 10 with genotype 4. HBsAg levels remained elevated despite a significant decline of plasma HBV DNA load with combination antiretroviral therapy that contained lamivudine and/or tenofovir. Conclusions: Our findings show that the incidence of recent HDV infection in HIV/HBV-coinfected patients increased significantly from 1992-2001 to 2007-2011, and was associated with hepatitis flares and syphilis. ? The Author 2014, Published by Oxford University Press on behalf of the Infectious Diseases Society of America, All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84900419809&doi=10.1093%2fcid%2fciu127&partnerID=40&md5=c6626b7851485103928c01e78bc581b7 https://scholars.lib.ntu.edu.tw/handle/123456789/588820 |
ISSN: | 1058-4838 | DOI: | 10.1093/cid/ciu127 | SDG/Keyword: | aminotransferase; antiretrovirus agent; bilirubin; hepatitis B surface antigen; immunoglobulin G antibody; integrase inhibitor; lamivudine plus tenofovir disoproxil; nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; reaginic antibody; RNA directed DNA polymerase inhibitor; hepatitis antibody; virus DNA; virus RNA; adult; antibody titer; article; controlled study; delta agent hepatitis; disease exacerbation; endemic disease; female; follow up; genotype; hepatitis B; Hepatitis B virus; Hepatitis delta virus; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; major clinical study; male; mixed infection; nonhuman; phylogeny; priority journal; seroconversion; superinfection; syphilis; viremia; virus load; blood; case control study; classification; cohort analysis; complication; DNA sequence; genetics; hepatitis B; Hepatitis D; Human immunodeficiency virus infection; immunology; isolation and purification; middle aged; molecular genetics; plasma; retrospective study; risk factor; virology; Adult; Case-Control Studies; Cohort Studies; DNA, Viral; Female; Hepatitis Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D; Hepatitis Delta Virus; HIV Infections; Humans; Incidence; Male; Middle Aged; Molecular Sequence Data; Phylogeny; Plasma; Retrospective Studies; Risk Factors; RNA, Viral; Sequence Analysis, DNA; Viral Load |
Appears in Collections: | 醫學系 |
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