https://scholars.lib.ntu.edu.tw/handle/123456789/588923
標題: | Cytological diagnosis of Penicillium marneffei infection | 作者: | I-SHIOW JAN Chung P.-F. JANN-YUAN WANG Weng M.-H. CHIEN-CHING HUNG LI-NA LEE |
公開日期: | 2008 | 出版社: | Scientific Communications International Ltd | 卷: | 107 | 期: | 6 | 起(迄)頁: | 443-447 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Penicillium marneffei is an emerging opportunistic pathogen. The goal of this study was to study its clinical and radiographic presentation, and the diagnostic value of a cytological study of penicilliosis. Methods: A total of 24 patients with penicilliosis were found by culture in an 8-year period. Thirteen patients had cytological examination, which were retrospectively reviewed to analyze the morphological characteristics of P. marneffei and diagnostic yields of different cytological specimens. Results: Twenty (83%) of the 24 patients (20 males) had human immunodeficiency virus (HIV) infection. In eight (40%) patients, penicilliosis was the initial manifestation of HIV infection. Penicilliosis was diagnosed in all patients antemortem from culture of blood or other body sites. One (4%) died. Six of 13 patients who had cytological study had intra- or extracellular yeast-like organisms with transverse septum found in fine needle aspirate, imprint or sputum cytology studies. The cytological diagnostic yields for P. marneffei from lung biopsy imprint smears, lung aspirates, neck lymph node aspirates and sputum were 2/2, 2/4, 2/2 and 2/4, respectively. The cytological diagnosis could be made immediately after aspiration, much quicker than diagnosis from cultures. Conclusion: P. marneffei causes disseminated infection, and can be the initial manifestation in HIV-infected patients in Taiwan. Penicilliosis can be diagnosed rapidly with cytological study of lung biopsy imprint smears, lung aspirates, neck lymph node aspirates or sputum. ?2008 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-48049116876&doi=10.1016%2fS0929-6646%2808%2960151-5&partnerID=40&md5=5d0688f85e4e5161ca4fab484b4164ee https://scholars.lib.ntu.edu.tw/handle/123456789/588923 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(08)60151-5 | SDG/關鍵字: | antifungal agent; article; aspiration cytology; blood culture; clinical article; clinical feature; computer assisted tomography; cytodiagnosis; diagnostic value; female; fungal morphology; fungus culture; fungus identification; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; human tissue; lung aspiration; lung biopsy; lymph node biopsy; male; mycosis; penicilliosis; Penicillium marneffei; retrospective study; sputum cytodiagnosis; Taiwan; thorax radiography |
顯示於: | 醫學系 |
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