https://scholars.lib.ntu.edu.tw/handle/123456789/590449
標題: | Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: A randomized, multicenter, double-blind controlled trial | 作者: | Pan W.-H. Lai Y.-H. Yeh W.-T. Chen J.-R. JIANN-SHING JENG Bai C.-H. Lin R.-T. Lee T.-H. Chang K.-C. Lin H.-J. Hsiao C.-F. Chern C.-M. Lien L.-M. Liu C.-H. Chen W.-H. Chang A. |
公開日期: | 2017 | 卷: | 106 | 期: | 5 | 起(迄)頁: | 1267-1273 | 來源出版物: | American Journal of Clinical Nutrition | 摘要: | Background: Stroke is one of the leading causes of mortality and neurologic deficits. Management measures to improve neurologic outcomes are in great need. Our previous intervention trial in elderly subjects successfully used salt as a carrier for potassium, demonstrating a 41% reduction in cardiovascular mortality by switching to potassium-enriched salt. Dietary magnesium has been associated with lowered diabetes and/or stroke risk in humans and with neuroprotection in animals. Objective: Because a large proportion of Taiwanese individuals are in marginal deficiency states for potassium and for magnesium and salt is a good carrier for minerals, it is justifiable to study whether further enriching salt with magnesium at an amount near the Dietary Reference Intake (DRI) amount may provide additional benefit for stroke recovery. Design: This was a double-blind, randomized controlled trial comprising 291 discharged stroke patients with modified Rankin scale (mRS) ?4. There were 3 arms: 1) regular salt (Na salt) (n = 99), 2) potassium-enriched salt (K salt) (n = 97), and 3) potassium- and magnesium-enriched salt (K/Mg salt) (n = 95). The NIH Stroke Scale (NIHSS), Barthel Index (BI), and mRS were evaluated at discharge, at 3 mo, and at 6 mo. A good neurologic performance was defined by NIHSS = 0, BI = 100, and mRS ?1. Results: After the 6-mo intervention, the proportion of patients with good neurologic performance increased in a greater magnitude in the K/Mg salt group than in the K salt group and the Na salt group, in that order. The K/Mg salt group had a significantly increased OR (2.25; 95% CI: 1.09, 4.67) of achieving good neurologic performance compared with the Na salt group. But the effect of K salt alone (OR: 1.58; 95% CI: 0.77, 3.22) was not significant. Conclusions: This study suggests that providing the DRI amount of magnesium and potassium together long term is beneficial for stroke patient recovery from neurologic deficits. This trial was registered at clinicaltrials.gov as NCT02910427. ? 2017 American Society for Nutrition. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033234935&doi=10.3945%2fajcn.116.148536&partnerID=40&md5=f3fadd7286161a9af4800da92b6eb0c7 https://scholars.lib.ntu.edu.tw/handle/123456789/590449 |
ISSN: | 29165 | DOI: | 10.3945/ajcn.116.148536 | SDG/關鍵字: | magnesium derivative; magnesium enriched salt; potassium derivative; potassium enriched salt; sodium chloride; unclassified drug; inorganic salt; magnesium; adult; Article; Barthel index; brain function; brain hemorrhage; brain ischemia; comparative study; controlled study; convalescence; dietary reference intake; double blind procedure; female; functional status; hospital discharge; human; magnesium intake; major clinical study; male; middle aged; multicenter study; National Institutes of Health Stroke Scale; potassium intake; randomized controlled trial; Rankin scale; stroke patient; unspecified side effect; administration and dosage; aged; Asian continental ancestry group; blood; cerebrovascular accident; clinical trial; drug effects; potassium intake; risk factor; statistical model; Taiwan; treatment outcome; Aged; Asian Continental Ancestry Group; Double-Blind Method; Female; Humans; Logistic Models; Magnesium; Male; Middle Aged; Potassium, Dietary; Recommended Dietary Allowances; Recovery of Function; Risk Factors; Salts; Stroke; Taiwan; Treatment Outcome |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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