Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
Journal
Nutrients
Journal Volume
13
Journal Issue
11
Date Issued
2021-11-01
Author(s)
Lin, Chen-Yu
Chung, Yao-Pang
Liu, Chia-Hung
Huang, Kuo-Tong
Guan, Siao-Syun
Wu, Cheng-Tien
Abstract
Nootkatone is one of the major active ingredients of Alpiniae oxyphyllae, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.
Subjects
apoptosis; chronic kidney disease; inflammation; nootkatone; renal fibrosis
Apoptosis; Chronic kidney disease; Inflammation; Nootkatone; Renal fibrosis
SDGs
Other Subjects
antiinflammatory agent; candesartan; nootkatone; protective agent; unclassified drug; Alpiniae oxyphyllae; animal experiment; animal model; antiinflammatory activity; apoptosis; Article; cell infiltration; controlled study; drug effect; drug efficacy; extracellular matrix; in vivo study; kidney fibrosis; male; medicinal plant; mouse; nephritis; nonhuman; oxidative stress; protein expression; renal protection; ureter obstruction
Publisher
MDPI
Type
journal article