https://scholars.lib.ntu.edu.tw/handle/123456789/592397
Title: | Mutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA | Authors: | LI-CHUN CHANG HAN-MO CHIU CHIA-TUNG SHUN JIN-TUNG LIANG Lin, Jaw-Town CHIEN-CHUAN CHEN YI-CHIA LEE MING-SHIANG WU |
Keywords: | Gene mutation; Non-polypoid colorectal neoplasm; EGFR; LATERALLY-SPREADING TUMORS; K-RAS MUTATIONS; CHINESE POPULATION; SERRATED PATHWAY; COLON CANCERS; POOR SURVIVAL; STOOL DNA; FLAT; CARCINOMA; PREVALENCE | Issue Date: | 31-Dec-2014 | Publisher: | BIOMED CENTRAL LTD | Journal Volume: | 14 | Start page/Pages: | 221 | Source: | BMC gastroenterology | Abstract: | Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/592397 | ISSN: | 1471-230X | DOI: | 10.1186/s12876-014-0221-y | SDG/Keyword: | B Raf kinase; epidermal growth factor receptor; epidermal growth factor receptor 2; protein kinase B; B Raf kinase; KRAS protein, human; oncoprotein; phosphatidylinositol 3 kinase; PIK3CA protein, human; Ras protein; adult; aged; AKT gene; Article; BRAF gene; cancer classification; cancer staging; carcinogenesis; colorectal adenoma; controlled study; disease severity; EGFR gene; epigenetics; exon; female; gene; genetic association; HER2 gene; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; middle aged; morphology; mutational analysis; oncogene K ras; PIK3CA gene; tumor volume; adenoma; colorectal tumor; genetics; mutation; nucleotide sequence; pathology; Adenoma; Aged; Colorectal Neoplasms; DNA Mutational Analysis; Female; Humans; Male; Middle Aged; Mutation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; ras Proteins |
Appears in Collections: | 醫學系 |
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