https://scholars.lib.ntu.edu.tw/handle/123456789/592628
標題: | Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases | 作者: | CHIH-FAN YEH Chang, Yu-Chen Eugene Lu, Cheng-Yuan Hsuan, Chin-Feng WEI-TIEN CHANG KAI-CHIEN YANG |
關鍵字: | Cardiovascular; Development; Disease; Long noncoding RNA | 公開日期: | 2-四月-2020 | 出版社: | BMC | 卷: | 27 | 期: | 1 | 起(迄)頁: | 48 | 來源出版物: | Journal of biomedical science | 摘要: | With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcribed, and a large proportion of the human genome is transcribed as long noncoding RNAs (lncRNAs), a heterogenous group of non-coding transcripts longer than 200 nucleotides. Emerging evidence suggests that lncRNAs are functional and contribute to the complex regulatory networks involved in cardiovascular development and diseases. In this article, we will review recent evidence on the roles of lncRNAs in the biological processes of cardiovascular development and disorders. The potential applications of lncRNAs as biomarkers and targets for therapeutics are also discussed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/592628 | ISSN: | 1423-0127 | DOI: | 10.1186/s12929-020-00647-w | SDG/關鍵字: | beta secretase 1; gap junction protein; long untranslated RNA; myocardin; polycomb repressive complex 2; sarcoplasmic reticulum calcium transporting adenosine triphosphatase; biological marker; long untranslated RNA; arrhythmogenesis; atherosclerosis; cardiomyopathy; cardiovascular disease; coronary artery disease; end stage renal disease; endothelium cell; heart arrhythmia; heart development; heart failure; heart infarction; heart muscle fibrosis; heart ventricle hypertrophy; heart ventricle remodeling; high throughput sequencing; human; human genome; lipid metabolism; myocardial ischemia reperfusion injury; nonhuman; priority journal; prognosis; Review; RNA sequencing; tissue regeneration; vascular smooth muscle cell; animal; cardiovascular disease; gene expression profiling; genetics; metabolism; mouse; rat; Animals; Biomarkers; Cardiovascular Diseases; Gene Expression Profiling; Humans; Mice; Rats; RNA, Long Noncoding |
顯示於: | 醫學系 |
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