https://scholars.lib.ntu.edu.tw/handle/123456789/592633
Title: | Impact of conduction disturbances on left ventricular mass regression and geometry change following transcatheter aortic valve replacement | Authors: | Tsung-Yu Ko HSIEN-LI KAO Liu, Ying-Ju CHIH-FAN YEH CHING-CHANG HUANG YING-HSIEN CHEN CHI-SHENG HUNG CHIH-YANG CHAN Lin, Lung-Chun YIH-SHARNG CHEN MAO-SHIN LIN |
Keywords: | BUNDLE-BRANCH BLOCK; MYOCARDIAL-PERFUSION; IMPLANTATION; RECOMMENDATIONS; DYSSYNCHRONY; ASSOCIATION; OUTCOMES; SOCIETY; SYSTEM | Issue Date: | 18-Sep-2021 | Publisher: | NATURE PORTFOLIO | Journal Volume: | 11 | Journal Issue: | 1 | Start page/Pages: | 16778 | Source: | Scientific reports | Abstract: | Our study aimed to compare the difference of LV mass regression and remodeling in regard of conduction disturbances (CD) following transcatheter aortic valve replacement (TAVR). A prospective analysis of 152 consecutive TAVR patients was performed. 53 patients (34.9%) had CD following TAVR, including 30 (19.7%) permanent pacemaker implantation and 23 (15.2%) new left bundle branch block. In 123 patients with 1-year follow-up, significant improvement of LV ejection fraction (LVEF) (baseline vs 12-month: 65.1 ± 13.2 vs 68.7 ± 9.1, P = 0.017) and reduced LV end-systolic volume (LVESV) (39.8 ± 25.8 vs 34.3 ± 17.1, P = 0.011) was found in non-CD group (N = 85), but not in CD group (N = 38). Both groups had significant decrease in LV mass index (baseline vs 12-month: 148.6 ± 36.9 vs. 136.4 ± 34.7 in CD group, p = 0.023; 153.0 ± 50.5 vs. 125.6 ± 35.1 in non-CD group, p < 0.0001). In 46 patients with 3-year follow-up, only non-CD patients (N = 28) had statistically significant decrease in LV mass index (Baseline vs 36-month: 180.8 ± 58.8 vs 129.8 ± 39.1, p = 0.0001). Our study showed the improvement of LV systolic function, reduced LVESV and LV mass regression at 1 year could be observed in patients without CD after TAVR. Sustained LV mass regression within 3-year was found only in patients without CD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/592633 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-96297-5 | SDG/Keyword: | aged; artificial heart pacemaker; clinical trial; female; follow up; heart left ventricle function; heart muscle conduction disturbance; heart ventricle; heart ventricle remodeling; human; male; pathophysiology; transcatheter aortic valve implantation; very elderly; Aged; Aged, 80 and over; Cardiac Conduction System Disease; Female; Follow-Up Studies; Heart Ventricles; Humans; Male; Pacemaker, Artificial; Transcatheter Aortic Valve Replacement; Ventricular Function, Left; Ventricular Remodeling |
Appears in Collections: | 醫學系 |
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