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  1. NTU Scholars
  2. 法律學院
  3. 法律學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/592906
Title: Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy
Authors: Ke, Chiao Hsu
Tomiyasu, Hirotaka
Lin, Yu Ling
WEI-HSIANG HUANG
Huang, Hsiao Hsuan
Chiang, Hsin Chien
CHEN-SI LIN
Keywords: Canine tumour model | cDNA microarray | Immunoediting | Infectious cancer | Tumour biomarkers;Canine tumour model; cDNA microarray; Immunoediting; Infectious cancer; Tumour biomarkers
Issue Date: 1-Dec-2022
Journal Volume: 18
Journal Issue: 1
Source: BMC Veterinary Research
Abstract: 
Background: Canine transmissible venereal tumours (CTVTs) can cross the major histocompatibility complex barrier to spread among dogs. In addition to the transmissibility within canids, CTVTs are also known as a suitable model for investigating the tumour–host immunity interaction because dogs live with humans and experience the same environmental risk factors for tumourigenesis. Moreover, outbred dogs are more appropriate than inbred mice models for simulating the diversity of human cancer development. This study built a new model of CTVTs, known as MCTVTs, to further probe the shaping effects of immune stress on tumour development. For xenotransplantation, CTVTs were first injected and developed in immunodeficient mice (NOD.CB17-Prkdcscid/NcrCrl), defined as XCTVTs. The XCTVTs harvested from NOD/SCID mice were then inoculated and grown in beagles and named mouse xenotransplantation of CTVTs (MCTVTs). Results: After the inoculation of CTVTs and MCTVTs into immune-competent beagle dogs separately, MCTVTs grew faster and metastasized more frequently than CTVTs did. Gene expression profiles in CTVTs and MCTVTs were analysed by cDNA microarray to reveal that MCTVTs expressed many tumour-promoting genes involved in chronic inflammation, chemotaxis, extracellular space modification, NF-kappa B pathways, and focal adhesion. Furthermore, several well-known tumour-associated biomarkers which could predict tumour progression were overexpressed in MCTVTs. Conclusions: This study demonstrated that defective host immunity can result in gene instability and enable transcriptome reprogramming within tumour cells. Fast tumour growth in beagle dogs and overexpression of tumour-associated biomarkers were found in a CTVT strain previously established in immunodeficient mice. In addition, dysregulated interaction of chronic inflammation, chemotaxis, and extracellular space modification were revealed to imply the possibly exacerbating mechanisms in the microenvironments of these tumours. In summary, this study offers a potential method to facilitate tumour progression and provide a niche for discovering tumour-associated biomarkers in cancer research.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/592906
DOI: 10.1186/s12917-021-03093-4
metadata.dc.subject.other: apolipoprotein C1; ELAV like protein 2; interstitial collagenase; kynurenine 3 monooxygenase; tumor marker; animal cell; animal experiment; animal model; animal tissue; Article; beagle; bioinformatics; cancer model; cancer research; Canidae; canine transm
[SDGs]SDG3
Appears in Collections:法律學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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