https://scholars.lib.ntu.edu.tw/handle/123456789/593253
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | SHYH-CHYI LO | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.contributor.author | Tseng P.-T. | en_US |
dc.contributor.author | Lai M.-Y. | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | Shiou-Hwei Yeh | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | DING-SHINN CHEN | en_US |
dc.date.accessioned | 2022-01-24T09:32:17Z | - |
dc.date.available | 2022-01-24T09:32:17Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984541353&doi=10.1016%2fj.jhep.2005.06.016&partnerID=40&md5=d18944f416f5e0fc48bb9974c2f1472c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/593253 | - |
dc.description.abstract | Background/Aims: The infectivity of occult hepatitis B virus (HBV), defined as HBsAg-negative but HBV DNA-positive, after transfusion has been low but not negligible. To address this, we investigated the incidence of post-transfusion HBV infection after receiving screened blood units in Taiwan. Methods: Consecutive HBV-na?ve (anti-HBc-negative) recipients with normal ALT were followed for HBV DNA and serologic markers before and after transfusion. Among 4448 blood recipients, 467 (10.5%) were anti-HBc-negative. Post-transfusion 6-month follow-up was completed for 327. We identified 5 (1.5%) who developed hepatitis B viremia 1 week after transfusion. Three were children who later seroconverted to anti-HBc but with normal ALT indicating subclinical acute infection, despite all had anti-HBs from previous vaccination. One had transient transfusion-transmitted HBV without seroconversion to anti-HBc and one possibly had occult HBV infection. Our findings suggested the possibility that occult HBV infection was transmissible by transfusion. The incidence of post-transfusion acute HBV infection was 0.9% (100 per million units) in na?ve recipients in Taiwan, a figure 7?40-fold higher than in developed countries. Moreover, some vaccinated children with anti-HBs were still susceptible. Conclusions: Therefore, despite active immunization, sensitive screening assays for occult HBV infection such as nucleic acid amplification test could be considered in endemic areas. ? 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Journal of Hepatology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; virus DNA; adolescent; adult; article; blood transfusion; child; clinical article; controlled study; female; follow up; hepatitis B; Hepatitis B virus; human; incidence; male; priority journal; recipient; screening test; serology; Taiwan; vaccination; viremia; virus transmission | - |
dc.title | Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jhep.2005.06.016 | - |
dc.identifier.pmid | 16168517 | - |
dc.identifier.scopus | 2-s2.0-84984541353 | - |
dc.relation.pages | 39-46 | en_US |
dc.relation.journalvolume | 44 | en_US |
dc.relation.journalissue | 1 | en_US |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.orcid | 0000-0002-6745-5953 | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0003-4509-180X | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0001-7791-6154 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床醫學研究所 |
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