Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse
Journal
Fluids and barriers of the CNS
Journal Volume
19
Journal Issue
1
Date Issued
2022-01-06
Author(s)
Kung, Yi
Liao, Wei-Hao
Hsu, Yi-Hua
Abstract
The blood-cerebrospinal fluid (CSF) barrier (BCSFB) is critically important to the pathophysiology of the central nervous system (CNS). However, this barrier prevents the safe transmission of beneficial drugs from the blood to the CSF and thus the spinal cord and brain, limiting their effectiveness in treating a variety of CNS diseases.
Subjects
Blood-cerebrospinal fluid barrier; Blood–brain barrier; Central nervous system; Glioblastoma multiforme; Leptomeningeal carcinomatosis; Low-energy extracorporeal focused shockwave pulse
Publisher
BMC
Type
journal article