https://scholars.lib.ntu.edu.tw/handle/123456789/593932
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tsai, Chang-Youh | en_US |
dc.contributor.author | CHIEH-YU SHEN | en_US |
dc.contributor.author | Liu, Chih-Wei | en_US |
dc.contributor.author | SONG-CHOU HSIEH | en_US |
dc.contributor.author | Liao, Hsien-Tzung | en_US |
dc.contributor.author | KO-JEN LI | en_US |
dc.contributor.author | Lu, Cheng-Shiun | en_US |
dc.contributor.author | Lee, Hui-Ting | en_US |
dc.contributor.author | Lin, Cheng-Sung | en_US |
dc.contributor.author | CHENG-HAN WU | en_US |
dc.contributor.author | YU-MIN KUO | en_US |
dc.contributor.author | CHIA-LI YU | en_US |
dc.date.accessioned | 2022-02-09T07:13:10Z | - |
dc.date.available | 2022-02-09T07:13:10Z | - |
dc.date.issued | 2020-12-06 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/593932 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with heterogeneous clinical manifestations. A diverse innate and adaptive immune dysregulation is involved in the immunopathogenesis of SLE. The dysregulation of immune-related cells may derive from the intricate interactions among genetic, epigenetic, environmental, and immunological factors. Of these contributing factors, non-coding RNAs (ncRNAs), including microRNAs (miRNAs, miRs), and long non-coding RNAs (lncRNAs) play critical roles in the post-transcriptional mRNA expression of cytokines, chemokines, and growth factors, which are essential for immune modulation. In the present review, we emphasize the roles of ncRNA expression in the immune-related cells and cell-free plasma, urine, and tissues contributing to the immunopathogenesis and tissue damage in SLE. In addition, the circular RNAs (circRNA) and their post-translational regulation of protein synthesis in SLE are also briefly described. We wish these critical reviews would be useful in the search for biomarkers/biosignatures and novel therapeutic strategies for SLE patients in the future. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Biomolecules | en_US |
dc.subject | SLE; autoimmunity; circRNA; epigenetic regulation; lncRNA; miRNA; ncRNA | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; chemokine; circular ribonucleic acid; growth factor; long untranslated RNA; messenger RNA; microRNA; untranslated RNA; chemokine; long untranslated RNA; messenger RNA; microRNA; signal peptide; autoimmune disease; autoimmunity; B lymphocyte; carcinogenesis; controlled study; DNA methylation; environmental factor; epigenetics; gene expression; genetic transcription; genome-wide association study; heredity; histone modification; human; immune dysregulation; immunomodulation; immunopathogenesis; macrophage; mental stress; mRNA expression level; natural killer cell; neutrophil; protein expression; protein function; protein processing; protein synthesis; Review; sequence analysis; systemic lupus erythematosus; T lymphocyte; tissue injury; Zika virus; adaptive immunity; blood; dendritic cell; gene expression regulation; genetics; immunology; innate immunity; pathology; systemic lupus erythematosus; Adaptive Immunity; Autoimmunity; Chemokines; Dendritic Cells; Gene Expression Regulation; Humans; Immunity, Innate; Intercellular Signaling Peptides and Proteins; Killer Cells, Natural; Lupus Erythematosus, Systemic; MicroRNAs; Neutrophils; RNA, Circular; RNA, Long Noncoding; RNA, Messenger; T-Lymphocytes | - |
dc.title | Aberrant Non-Coding RNA Expression in Patients with Systemic Lupus Erythematosus: Consequences for Immune Dysfunctions and Tissue Damage | en_US |
dc.type | journal article | en |
dc.type | review | en_US |
dc.identifier.doi | 10.3390/biom10121641 | - |
dc.identifier.pmid | 33291347 | - |
dc.identifier.scopus | 2-s2.0-85097405666 | - |
dc.identifier.isi | WOS:000601864300001 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/543392 | - |
dc.relation.pages | 1641 | en_US |
dc.relation.journalvolume | 10 | en_US |
dc.relation.journalissue | 12 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Molecular Medicine | - |
crisitem.author.orcid | 0000-0002-3218-0689 | - |
crisitem.author.orcid | 0000-0002-4544-4620 | - |
crisitem.author.orcid | 0000-0002-1513-8657 | - |
crisitem.author.orcid | 0000-0002-5797-6093 | - |
crisitem.author.orcid | 0000-0003-4988-0400 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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