https://scholars.lib.ntu.edu.tw/handle/123456789/594139
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsu M.-H. | en_US |
dc.contributor.author | Wang W.-L. | en_US |
dc.contributor.author | Chen T.-H. | en_US |
dc.contributor.author | Tai C.-M. | en_US |
dc.contributor.author | HSIU-PO WANG | en_US |
dc.contributor.author | Lee C.-T. | en_US |
dc.date.accessioned | 2022-02-14T05:27:15Z | - |
dc.date.available | 2022-02-14T05:27:15Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1471-230X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111999583&doi=10.1186%2fs12876-021-01888-1&partnerID=40&md5=643242badf9152d71b6e6e8ac62307bf | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/594139 | - |
dc.description.abstract | Background: Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reported outside Japan. Method: We consecutively recruited patients with SESCC who had received ESD treatment at E-Da Hospital. The demographics, pathological characteristics, and Lugol staining background pattern (type A or B: none or < 10 small Lugol-voiding lesions [LVLs]; type C or D: > 10 small or multiform LVLs) were collected, and then correlated to outcomes and survival. Results: Total of 229 lesions were enrolled and the mean lesion size was 3.28 ± 1.69 (range 1–10) cm. 72% of the lesions had a type C-D Lugol staining background pattern. After ESD, the en bloc and R0 resection rates were 93.9% and 83.5%, respectively. Forty-nine subjects developed complications, including six (2.6%) with major bleeding, two (0.9%) with perforation, and 41 (17.9%) with strictures. Pathological staging showed that 19 cases had deep submucosal cancer invasion and subsequently received adjuvant therapies. During a mean follow-up period of 52.6 (range 3–146) months, 41 patients developed metachronous recurrence. The patients with a type C-D Lugol staining background pattern were associated with a higher risk of recurrence than those with few LVLs (log-rank P = 0.019). The 10-year survival rate was more than 90%, and only eight patients died of ESCC. Conclusion: ESD has excellent long-term outcomes but a high risk of metachronous recurrence. The Lugol staining pattern over the background mucosa could offer the risk stratification of metachronous recurrence. ? 2021, The Author(s). | - |
dc.publisher | BioMed Central Ltd | - |
dc.relation.ispartof | BMC Gastroenterology | - |
dc.subject | Endoscopic submucosal dissection; Esophageal squamous cell carcinoma; Lugol-voiding lesions | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adverse event; endoscopic mucosal resection; esophageal squamous cell carcinoma; esophagus tumor; human; Japan; retrospective study; Taiwan; treatment outcome; tumor recurrence; Endoscopic Mucosal Resection; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Japan; Neoplasm Recurrence, Local; Retrospective Studies; Taiwan; Treatment Outcome | - |
dc.title | Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/s12876-021-01888-1 | - |
dc.identifier.pmid | 34344303 | - |
dc.identifier.scopus | 2-s2.0-85111999583 | - |
dc.relation.journalvolume | 21 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7741-9315 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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