https://scholars.lib.ntu.edu.tw/handle/123456789/595744
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Pai, Ming-Chyi | en_US |
dc.contributor.author | CHAU-CHUNG WU | en_US |
dc.contributor.author | Hou, Yi-Chou | en_US |
dc.contributor.author | JIANN-SHING JENG | en_US |
dc.contributor.author | SUNG-CHUN TANG | en_US |
dc.contributor.author | Lin, Wei-Che | en_US |
dc.contributor.author | Lu, Cheng-Hsien | en_US |
dc.contributor.author | MING-JANG CHIU | en_US |
dc.contributor.author | TA-FU CHEN | en_US |
dc.contributor.author | Yan, Sui-Hing | en_US |
dc.contributor.author | Hu, Chaur-Jong | en_US |
dc.contributor.author | Yang, Shieh-Yueh | en_US |
dc.date.accessioned | 2022-02-24T05:42:03Z | - |
dc.date.available | 2022-02-24T05:42:03Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/595744 | - |
dc.description.abstract | Subjects with comorbidities are at risk for neurodegeneration. There is a lack of a direct relationship between comorbidities and neurodegeneration. In this study, immunomagnetic reduction (IMR) assays were utilized to assay plasma Aβ1-42 and total tau protein (T-Tau) levels in poststroke (PS, n = 27), family history of Alzheimer's disease (ADFH, n = 35), diabetes (n = 21), end-stage renal disease (ESRD, n = 41), obstructive sleep apnea (OSA, n = 20), Alzheimer's disease (AD, n = 65). Thirty-seven healthy controls (HCs) were enrolled. The measured concentrations of plasma Aβ1-42 were 14.26 ± 1.42, 15.43 ± 1.76, 15.52 ± 1.60, 16.15 ± 1.05, 16.52 ± 0.59, 15.97 ± 0.54 and 20.06 ± 3.09 pg/mL in HC, PS, ADFH, diabetes, ESRD, OSA and AD groups, respectively. The corresponding concentrations of plasma T-Tau were 15.13 ± 3.62, 19.29 ± 8.01, 17.93 ± 6.26, 19.74 ± 2.92, 21.54 ± 2.72, 20.17 ± 2.77 and 41.24 ± 14.64 pg/mL. The plasma levels of Aβ1-42 and T-Tau in were significantly higher in the PS, ADFH, diabetes, ESRD and OSA groups than controls (Aβ1-42 in PS: 15.43 ± 1.76 pg/mL vs. 14.26 ± 1.42 pg/mL, p < 0.005; T-Tau in PS: 19.29 ± 8.01 vs. 15.13 ± 3.62 pg/mL, p < 0.005, Aβ1-42 in ADFH: 15.52 ± 1.60 pg/mL vs. 14.26 ± 1.42 pg/mL, p < 0.001; T-Tau in ADFH: 17.93 ± 6.26 vs. 15.13 ± 3.62 pg/mL, p < 0.005, Aβ1-42 in diabetes: 16.15 ± 1.05 pg/mL vs. 14.26 ± 1.42 pg/mL, p < 0.001; T-Tau in diabetes: 19.74 ± 2.92 vs. 15.13 ± 3.62 pg/mL, p < 0.001, Aβ1-42 in ESRD: 16.52 ± 0.59 pg/mL vs. 14.26 ± 1.42 pg/mL, p < 0.001; T-Tau in ESRD: 21.54 ± 2.72 vs. 15.13 ± 3.62 pg/mL, p < 0.001, Aβ1-42 in OSA: 15.97 ± 0.54 pg/mL vs. 14.26 ± 1.42 pg/mL, p < 0.001; T-Tau in OSA: 20.17 ± 2.77 vs. 15.13 ± 3.62 pg/mL, p < 0.001). This evidence indicates the high risk for dementia in these groups from the perspective of plasma biomarkers. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.subject | ALZHEIMERS-DISEASE; AMYLOID-BETA; OLIGOMERS; PEOPLE; TAU; PET | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-022-05177-z | - |
dc.identifier.pmid | 35075194 | - |
dc.identifier.isi | WOS:000746700700059 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/594385 | - |
dc.relation.pages | 1192 | en_US |
dc.relation.journalvolume | 12 | en_US |
dc.relation.journalissue | 1 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.orcid | 0000-0001-8191-475X | - |
crisitem.author.orcid | 0000-0002-1456-3686 | - |
crisitem.author.orcid | 0000-0003-3731-5973 | - |
crisitem.author.orcid | 0000-0002-4158-4423 | - |
crisitem.author.orcid | 0000-0003-1988-6924 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學教育暨生醫倫理學科所 |
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