https://scholars.lib.ntu.edu.tw/handle/123456789/595883
Title: | Probing invadosomes: technologies for the analysis of invadosomes | Authors: | Lin, Shan-Shan Su, You-An Chuang, Mei-Chun YA-WEN LIU |
Keywords: | focal adhesion; invadosome dynamics; proteolytic activity; protrusive force; stiffness | Issue Date: | 1-Oct-2022 | Publisher: | WILEY | Journal Volume: | 289 | Journal Issue: | 19 | Start page/Pages: | 5850 - 5863 | Source: | The FEBS journal | Abstract: | Invadosomes are protrusive and mechanosensitive actin devices critical for cell migration, invasion, and extracellular matrix remodeling. The dynamic, proteolytic, and protrusive natures of invadosomes have made these structures fascinating and attracted many scientists to develop new technologies for their analysis. With these exciting methodologies, many biochemical and biophysical properties of invadosomes have been well characterized and appreciated, and those discoveries elegantly explained the biological and pathological effects of invadosomes in human health and diseases. In this review, we focus on these commonly used or newly developed methods for invadosome analysis and effort to reason some discrepancies among those assays. Finally, we explore the opposite regulatory mechanisms among invadosomes and focal adhesions, another actin-rich adhesive structures, and speculate a potential rule for their switch. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/595883 | ISSN: | 1742-464X 1742-4658 |
DOI: | 10.1111/febs.16098 |
Appears in Collections: | 分子醫學研究所 |
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