https://scholars.lib.ntu.edu.tw/handle/123456789/596367
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu H.-C. | en_US |
dc.contributor.author | Lin Y.-J. | en_US |
dc.contributor.author | Lee J.-J. | en_US |
dc.contributor.author | Liu Y.-J. | en_US |
dc.contributor.author | Liang S.-T. | en_US |
dc.contributor.author | Peng Y. | en_US |
dc.contributor.author | Chiu Y.-W. | en_US |
dc.contributor.author | Wu C.-W. | en_US |
dc.contributor.author | CHIN-TARNG LIN | en_US |
dc.date.accessioned | 2022-03-04T06:10:57Z | - |
dc.date.available | 2022-03-04T06:10:57Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0038002724&doi=10.1097%2f01.LAB.0000074896.03561.FB&partnerID=40&md5=858fc755c4ccff9db6d65f70d1c9fae7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/596367 | - |
dc.description.abstract | A membrane invasion culture system was used to study the ability of EBV to enhance invasion and migration of nasopharyngeal carcinoma (NPC) cells. Semi-reverse transcriptase-PCR analysis of matrix proteinases and angiogenic factors from EBV-infected, or EBV-positive (EBV+), cells demonstrated different degrees of elevated gene expression. In our animal model, EBV+ tumors grew faster and larger than EBV-free, or EBV-negative (EBV-), tumors and also had clonal EBV terminal repeat sequences. Double-localization of EBV and certain host proteins in EBV+ tumors and biopsy specimens demonstrated that EBV up-regulates host genes only in cells that express those genes but not in cells that do not express them. Double-localization of EBV and host genes in NPC biopsy specimens all showed EBV-tumor cells expressing those host genes. Our data strongly suggest that EBV infection enhances progression of NPC tumor growth. They do not rule out a role for EBV infection in the induction and early promotion of NPC development. Unidentified factors may also enhance NPC tumor growth independent of the effects of EBV. | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.relation.ispartof | Laboratory Investigation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | angiogenic factor; matrix metalloproteinase; animal model; animal tissue; article; cancer cell culture; carcinoma cell; cell growth; cell invasion; cell migration; cell structure; controlled study; Epstein Barr virus; gene expression; gene expression regulation; human; human cell; long terminal repeat; mouse; nasopharynx carcinoma; nonhuman; priority journal; protein localization; reverse transcription polymerase chain reaction; SCID mouse; solid tumor; tumor growth; tumor promotion; virus carcinogenesis; virus detection; virus genome; virus infection | - |
dc.title | Functional analysis of EBV in nasopharyngeal carcinoma cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1097/01.LAB.0000074896.03561.FB | - |
dc.identifier.pmid | 12808115 | - |
dc.identifier.scopus | 2-s2.0-0038002724 | - |
dc.relation.pages | 797-812 | - |
dc.relation.journalvolume | 83 | - |
dc.relation.journalissue | 6 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.orcid | 0000-0003-3928-1412 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 病理學科所 |
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