https://scholars.lib.ntu.edu.tw/handle/123456789/596983
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsiung C.-N. | en_US |
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | Lin C.-W. | en_US |
dc.contributor.author | Chang C.-W. | en_US |
dc.contributor.author | Chou W.-C. | en_US |
dc.contributor.author | Chu H.-W. | en_US |
dc.contributor.author | Su M.-W. | en_US |
dc.contributor.author | Wu P.-E. | en_US |
dc.contributor.author | Shen C.-Y. | en_US |
dc.date.accessioned | 2022-03-10T05:59:24Z | - |
dc.date.available | 2022-03-10T05:59:24Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080853249&doi=10.1210%2fclinem%2fdgz243&partnerID=40&md5=00e918453a4986a97b1d3209a7e7092b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/596983 | - |
dc.description.abstract | Context: The association between circulating triglyceride (TG) and glycated hemoglobin A1c (HbA1c), a biomarker for type 2 diabetes, has been widely addressed, but the causal direction of the relationship is still ambiguous. Objective: To confirm the causal relationship between TG and HbA1c by using bidirectional and 2-step Mendelian randomization (MR) approaches. Methods: We carried out a bidirectional MR approach using the summarized results from the public database to examine any potential causal effects between serum TG and HbA1c in 16 000 individuals of the Taiwan Biobank cohort. We used the MR estimate and the MR inverse variance-weighted method to reveal that relationship between TG and HbA1c. To further determine whether the DNA methylation at specific sequences mediate the causal pathway between TG and HbA1c, using the 2-step MR approach. Results: We identified that a single-unit increase in TG measured via log transformation of mg/dL data was associated with a significant increase of 10 units of HbA1c (95% CI = 1.05-18.95, P = 0.029). In contrast, the genetic determinants of HbA1c do not contribute to the amount of circulating TG (beta = 1.75, 95% CI = -11.50 to 14.90). Sensitivity analyses, included the weighted-median approach and MR-Egger regression, were performed to confirm no pleiotropic effect among these instrumental variables. Furthermore, we identified the genetic variant, rs1823200, is associated with both methylation of the CpG site adjacent to CADPS gene and HbA1c level. Conclusion: Our study suggests that higher circulating TG can have an affect on genomic methylation status, ultimately causing elevated level of circulating HbA1c. ? 2019 Endocrine Society 2019. | - |
dc.publisher | Endocrine Society | - |
dc.relation.ispartof | Journal of Clinical Endocrinology and Metabolism | - |
dc.subject | diabetes; HbA1c; Mendelian randomization; phenome-wide association study; triglyceride | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cholesterol; hemoglobin A1c; high density lipoprotein; low density lipoprotein; triacylglycerol; CADPS protein, human; calcium binding protein; glycosylated hemoglobin; hemoglobin A1c protein, human; triacylglycerol; vesicular transport protein; adult; Article; CADPS gene; causal relationship; cholesterol blood level; cohort analysis; controlled study; CpG island; disease association; disease registry; DNA methylation; epigenome; female; follow up; genetic variability; hemoglobin blood level; heredity; human; instrumental variable analysis; lipoprotein blood level; major clinical study; male; Mendelian randomization analysis; middle aged; nucleotide sequence; pleiotropy; priority journal; quantitative trait locus; sensitivity analysis; Taiwan; triacylglycerol blood level; validation study; biobank; blood; genetic predisposition; genetic variation; genetics; hyperlipidemia; non insulin dependent diabetes mellitus; regression analysis; Adult; Biological Specimen Banks; Calcium-Binding Proteins; CpG Islands; Diabetes Mellitus, Type 2; DNA Methylation; Female; Genetic Predisposition to Disease; Genetic Variation; Glycated Hemoglobin A; Humans; Hyperlipidemias; Male; Mendelian Randomization Analysis; Middle Aged; Regression Analysis; Taiwan; Triglycerides; Vesicular Transport Proteins | - |
dc.title | The Causal Relationship of Circulating Triglyceride and Glycated Hemoglobin: A Mendelian Randomization Study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1210/clinem/dgz243 | - |
dc.identifier.pmid | 31784746 | - |
dc.identifier.scopus | 2-s2.0-85080853249 | - |
dc.relation.journalvolume | 105 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 基因體暨蛋白體醫學研究所 |
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