https://scholars.lib.ntu.edu.tw/handle/123456789/604540
Title: | Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer | Authors: | Huang, San-Shan Lee, Keng-Jung Chen, Hung-Chih Prajnamitra, Ray Putra Hsu, Chia-Hsin Jian, Cheng-Bang Yu, Xu-En Chueh, Di-Yen Kuo, Chiung Wen Chiang, Tsai-Chen Choong, Oi Kuan Huang, Shao-Chan Beh, Chaw Yee Chen, Li-Lun Lai, James J Chen, Peilin Kamp, Timothy J YU-WEN TIEN Lee, Hsien-Ming Hsieh, Patrick Ching-Ho |
Keywords: | MACROPHAGES; LIPOSOMES; APTAMERS; INJURY | Issue Date: | 2021 | Publisher: | AMER ASSOC ADVANCEMENT SCIENCE | Journal Volume: | 7 | Journal Issue: | 17 | Source: | Science advances | Abstract: | The delivery of therapeutics through the circulatory system is one of the least arduous and less invasive interventions; however, this approach is hampered by low vascular density or permeability. In this study, by exploiting the ability of monocytes to actively penetrate into diseased sites, we designed aptamer-based lipid nanovectors that actively bind onto the surface of monocytes and are released upon reaching the diseased sites. Our method was thoroughly assessed through treating two of the top causes of death in the world, cardiac ischemia-reperfusion injury and pancreatic ductal adenocarcinoma with or without liver metastasis, and showed a significant increase in survival and healing with no toxicity to the liver and kidneys in either case, indicating the success and ubiquity of our platform. We believe that this system provides a new therapeutic method, which can potentially be adapted to treat a myriad of diseases that involve monocyte recruitment in their pathophysiology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/604540 | ISSN: | 2375-2548 | DOI: | 10.1126/sciadv.abf2400 |
Appears in Collections: | 醫學系 |
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