https://scholars.lib.ntu.edu.tw/handle/123456789/605772
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JENG-WEI CHEN | en_US |
dc.contributor.author | NAI-KUAN CHOU | en_US |
dc.contributor.author | CHIH-HSIEN WANG | en_US |
dc.contributor.author | NAI-HSIN CHI | en_US |
dc.contributor.author | SHU-CHIEN HUANG | en_US |
dc.contributor.author | HSI-YU YU | en_US |
dc.contributor.author | YIH-SHARNG CHEN | en_US |
dc.contributor.author | RON-BIN HSU | en_US |
dc.date.accessioned | 2022-04-25T03:15:39Z | - |
dc.date.available | 2022-04-25T03:15:39Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 09340874 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/605772 | - |
dc.description.abstract | End stage renal disease (ESRD) is a contraindication to isolated heart transplantation (HT). However, heart candidates with cardiogenic shock may experience acute kidney injury and require renal replacement therapy (RRT) and isolated HT as a life-saving operation. The outcomes, including survival and renal function, are rarely reported. We enrolled 569 patients undergoing isolated HT from 1989 to 2018. Among them, 66 patients required RRT before HT (34 transient and 32 persistent). The survival was worse in patients with RRT than those without (65.2% vs 84.7%; 27.3% vs 51.1% at 1- and 10-year, p < 0.001 and p = 0.012, respectively). Multivariate Cox analysis identified pre-transplant hyperbilirubinemia (Hazard ratio (HR) 2.534, 95% confidence interval (CI) 1.098-5.853, p = 0.029), post-transplant RRT (HR 5.551, 95%CI 1.280-24.068, p = 0.022) and post-transplant early bloodstream infection (HR 3.014, 95%CI 1.270-7.152, p = 0.012) as independent risk factors of 1-year mortality. The majority of operative survivors (98%) displayed renal recovery after HT. Although patients with persistent or transient RRT before HT had a similar long-term survival, patients with persistent RRT developed a high incidence (49.2%) of dialysis-dependent ESRD at 10 years. In transplant candidates with pretransplant RRT, hyperbilirubinemia should be carefully re-evaluated for the eligibility of HT whereas prevention and management of bloodstream infection after HT improve survival. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Transplant international : official journal of the European Society for Organ Transplantation | en_US |
dc.subject | acute kidney injury; heart transplant; long term survival; renal failure; renal replacement therapy | en_US |
dc.title | Impact of Pretransplant Renal Replacement Therapy on Clinical Outcome After Isolated Heart Transplantation | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3389/ti.2022.10185 | - |
dc.identifier.pmid | 35387394 | - |
dc.identifier.scopus | 2-s2.0-85127718414 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/605618 | - |
dc.relation.journalvolume | 35 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0001-5648-9202 | - |
crisitem.author.orcid | 0000-0001-5494-7708 | - |
crisitem.author.orcid | 0000-0003-3214-6867 | - |
crisitem.author.orcid | 0000-0003-1829-6084 | - |
crisitem.author.orcid | 0000-0002-0590-3474 | - |
crisitem.author.orcid | 0000-0001-6669-4699 | - |
crisitem.author.orcid | 0000-0003-3846-8162 | - |
crisitem.author.orcid | 0000-0002-7794-497X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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