https://scholars.lib.ntu.edu.tw/handle/123456789/606000
標題: | Animal models of dry eye: Their strengths and limitations for studying human dry eye disease | 作者: | Chang Y.-A Wu Y.-Y CHUNG-TIEN LIN Kawasumi M Wu C.-H Kao S.-Y Yang Y.-P Hsu C.-C Hung K.-F Sun Y.-C. |
關鍵字: | Animal models;Aqueous-deficient type;Dry eye disease;Evaporative type;Keratoconjunctivitis sicca;acetylcysteine;benzalkonium chloride;eye drops;trichloroacetic acid;Article;dry eye;environmental stress;immune response;keratoconjunctivitis sicca;lacrimal gland;murine model;nonhuman;rabbit model;radiotherapy;surgical approach;systematic review;animal;disease model;Leporidae;mouse;pathophysiology;Animals;Disease Models, Animal;Dry Eye Syndromes;Mice;Rabbits | 公開日期: | 2021 | 卷: | 84 | 期: | 5 | 起(迄)頁: | 459-464 | 來源出版物: | Journal of the Chinese Medical Association | 摘要: | Dry eye disease (DED), also called the keratoconjunctivitis sicca, is one of the most common diseases in the ophthalmology clinics. While DED is not a life-threatening disease, life quality may be substantially affected by the discomfort and the complications of poor vision. As such, a large number of studies have made contributions to the investigation of the DED pathogenesis and novel treatments. DED is a multifactorial disease featured with various phenotypic consequences; therefore, animal models are valuable tools suitable for the related studies. Accordingly, selection of the animal model to recapitulate the clinical presentation of interest is important for appropriately addressing the research objective. To this end, we systemically reviewed different murine and rabbit models of DED, which are categorized into the quantitative (aqueous-deficient) type and the qualitative (evaporative) type, based on the schemes to establish. The clinical manifestations of dry eye on animal models can be induced by mechanical or surgical approaches, iatrogenic immune response, topical eye drops, blockage of neural pathway, or others. Although these models have shown promising results, each has its own limitation and cannot fully reproduce the pathophysiological mechanisms that occur in patients. Nonetheless, the animal models remain the best approximation of human DED and represent the valuable tool for the DED studies. ? 2021, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105772514&doi=10.1097%2fJCMA.0000000000000529&partnerID=40&md5=9ed0995dc2fb3f4556d391c06f2c5626 https://scholars.lib.ntu.edu.tw/handle/123456789/606000 |
ISSN: | 17264901 | DOI: | 10.1097/JCMA.0000000000000529 |
顯示於: | 臨床動物醫學研究所 |
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