https://scholars.lib.ntu.edu.tw/handle/123456789/606868
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen B.P.-W | en_US |
dc.contributor.author | He R.-Y | en_US |
dc.contributor.author | Chien H.-M | en_US |
dc.contributor.author | Lee C.-C | en_US |
dc.contributor.author | Chuang H.-H | en_US |
dc.contributor.author | Hsu C.-P | en_US |
dc.contributor.author | CHUN-CHUNG CHAN | en_US |
dc.contributor.author | Huang J.J.-T. | en_US |
dc.date.accessioned | 2022-04-25T06:38:54Z | - |
dc.date.available | 2022-04-25T06:38:54Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 25740970 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124120581&doi=10.1021%2facsanm.1c04004&partnerID=40&md5=37488d0ccb4b737a345d71f4e0843c3b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/606868 | - |
dc.description.abstract | We report the incorporation of salicylaldehyde derivatives onto the hydrazine-tagged amyloidogenic peptides by forming photoisomerizable hydrazones. These hydrazones with positive photochromism are photostable under physiological conditions and enable photoswitching without the addition of external reductants or high-power irradiation. By applying superresolution microscopy, we were able to distinguish polymorphic nanoscopic structures of the hydrazone-incorporated peptides in vitro under different buffer conditions. Moreover, the additive-free condition in our platform allows the exploration of detailed amyloid aggregate morphologies in live cells. ? | - |
dc.relation.ispartof | ACS Applied Nano Materials | - |
dc.subject | acylhydrazone | - |
dc.subject | amyloid | - |
dc.subject | fluorophore | - |
dc.subject | live-cell imaging | - |
dc.subject | peptide labeling | - |
dc.subject | photochromic | - |
dc.subject | superresolution | - |
dc.subject | Glycoproteins | - |
dc.subject | Image processing | - |
dc.subject | Nitrogen compounds | - |
dc.subject | Peptides | - |
dc.subject | Photochromism | - |
dc.subject | Acylhydrazone | - |
dc.subject | Condition | - |
dc.subject | Hydrazones | - |
dc.subject | Labelings | - |
dc.subject | Live-cell imaging | - |
dc.subject | Nano-fibrils | - |
dc.subject | Peptide labeling | - |
dc.subject | Photochromics | - |
dc.subject | Super resolution imaging | - |
dc.subject | Superresolution | - |
dc.subject | Optical resolving power | - |
dc.title | Superresolution Imaging of Photochromic Acylhydrazone Moieties on Amyloid Nanofibrils: Implications for Photoswitchable Probes | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acsanm.1c04004 | - |
dc.identifier.scopus | 2-s2.0-85124120581 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Chemistry | - |
crisitem.author.orcid | 0000-0002-5108-4166 | - |
crisitem.author.parentorg | College of Science | - |
顯示於: | 化學系 |
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