https://scholars.lib.ntu.edu.tw/handle/123456789/606878
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Mao J.-Y | en_US |
dc.contributor.author | Unnikrishnan B | en_US |
dc.contributor.author | Chu H.-W | en_US |
dc.contributor.author | Harroun S.G | en_US |
dc.contributor.author | Chen Y.-R | en_US |
dc.contributor.author | Wu A.-T | en_US |
dc.contributor.author | HUAN-TSUNG CHANG | en_US |
dc.contributor.author | Lin H.-J | en_US |
dc.contributor.author | Huang C.-C. | en_US |
dc.date.accessioned | 2022-04-25T06:38:59Z | - |
dc.date.available | 2022-04-25T06:38:59Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 20474830 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109105253&doi=10.1039%2fd1bm00402f&partnerID=40&md5=e44907494f86badf0630f9a2491840c7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/606878 | - |
dc.description.abstract | We have demonstrated that alginate with negligible anticoagulant activity can be converted into carbonized nanogels with potent anticoagulant activity through a solid-state heating process. The conversion of alginate into graphene-like nanosheet (GNS)-embedded polyphenolic-alginate nanogels (GNS/Alg-NGs) has been carried out through condensation and carbonization processes. The GNS/Alg-NGs exhibit much stronger anticoagulant activity (>520-fold) compared to untreated alginate, mainly because their polyphenolic structures have a high binding affinity [dissociation constant (Kd) = 2.1 × 10-10 M] toward thrombin. In addition, the thrombin clotting time delay caused by the GNS/Alg-NGs is 10-fold longer than that of natural polyphenolic compounds, such as quercetin, catechin, naringenin, caffeic acid, and ferulic acid. The thrombin-or kaolin-activated thromboelastography of whole-blood coagulation reveals that the GNS/Alg-NGs display a much stronger anticoagulant ability than that of untreated alginate and naturally sulfated polysaccharides (fucoidan). The GNS/Alg-NGs exhibit superior biocompatibility and anticoagulant activity, as observed with an in vivo rat model, revealing their potential as a blood thinner for the treatment of thrombotic disorders. ? The Royal Society of Chemistry. | - |
dc.relation.ispartof | Biomaterials Science | - |
dc.subject | Binding energy | - |
dc.subject | Biocompatibility | - |
dc.subject | Blood | - |
dc.subject | Carbonization | - |
dc.subject | Dissociation | - |
dc.subject | Enzymes | - |
dc.subject | Flavonoids | - |
dc.subject | Nanostructured materials | - |
dc.subject | Polyphenolic compounds | - |
dc.subject | Anticoagulant activities | - |
dc.subject | Binding affinities | - |
dc.subject | Carbonization process | - |
dc.subject | Dissociation constant | - |
dc.subject | Heating process | - |
dc.subject | Sulfated polysaccharides | - |
dc.subject | Thermally driven | - |
dc.subject | Thrombotic disorders | - |
dc.subject | Alginate | - |
dc.subject | alginic acid | - |
dc.subject | anticoagulant agent | - |
dc.subject | blood clotting factor 11 | - |
dc.subject | blood clotting factor 12 | - |
dc.subject | blood clotting factor 5 | - |
dc.subject | blood clotting factor 7 | - |
dc.subject | caffeic acid | - |
dc.subject | catechin | - |
dc.subject | enoxaparin | - |
dc.subject | ferulic acid | - |
dc.subject | fucoidin | - |
dc.subject | graphene like nanosheet polyphenolic alginate nanogel | - |
dc.subject | kaolin | - |
dc.subject | nanogel | - |
dc.subject | naringenin | - |
dc.subject | quercetin | - |
dc.subject | thrombin | - |
dc.subject | unclassified drug | - |
dc.subject | polysaccharide | - |
dc.subject | activated partial thromboplastin time | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | anticoagulation | - |
dc.subject | Article | - |
dc.subject | binding affinity | - |
dc.subject | biocompatibility | - |
dc.subject | bleeding | - |
dc.subject | blood clotting | - |
dc.subject | carbonization | - |
dc.subject | controlled study | - |
dc.subject | cytotoxicity | - |
dc.subject | embryo | - |
dc.subject | ex vivo study | - |
dc.subject | human | - |
dc.subject | human cell | - |
dc.subject | in vivo study | - |
dc.subject | male | - |
dc.subject | nonhuman | - |
dc.subject | prothrombin time | - |
dc.subject | rat | - |
dc.subject | sulfation | - |
dc.subject | tail bleeding time | - |
dc.subject | thrombin time | - |
dc.subject | thromboelastography | - |
dc.subject | animal | - |
dc.subject | Animals | - |
dc.subject | Anticoagulants | - |
dc.subject | Blood Coagulation | - |
dc.subject | Nanogels | - |
dc.subject | Polysaccharides | - |
dc.subject | Rats | - |
dc.subject | Thrombin | - |
dc.title | Thermally driven formation of polyphenolic carbonized nanogels with high anticoagulant activity from polysaccharides | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1039/d1bm00402f | - |
dc.identifier.pmid | 34018502 | - |
dc.identifier.scopus | 2-s2.0-85109105253 | - |
dc.relation.pages | 4679-4690 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 13 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Chemistry | - |
crisitem.author.orcid | 0000-0002-5393-1410 | - |
crisitem.author.parentorg | College of Science | - |
顯示於: | 化學系 |
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