https://scholars.lib.ntu.edu.tw/handle/123456789/609446
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Khoi, Chong-Sun | en_US |
dc.contributor.author | Chen, Jia-Huang | en_US |
dc.contributor.author | Lin, Tzu-Yu | en_US |
dc.contributor.author | CHIH-KANG CHIANG | en_US |
dc.contributor.author | KUAN-YU HUNG | en_US |
dc.date.accessioned | 2022-05-05T02:23:04Z | - |
dc.date.available | 2022-05-05T02:23:04Z | - |
dc.date.issued | 2021-10-18 | - |
dc.identifier.issn | 16616596 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/609446 | - |
dc.description.abstract | Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | International journal of molecular sciences | en_US |
dc.subject | molecular interaction; nephrotoxicity; ochratoxin A; prevention | en_US |
dc.title | Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence | en_US |
dc.type | journal article | en |
dc.type | review | en_US |
dc.identifier.doi | 10.3390/ijms222011237 | - |
dc.identifier.pmid | 34681895 | - |
dc.identifier.scopus | 2-s2.0-85117130809 | - |
dc.identifier.isi | WOS:000714429400001 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/596897 | - |
dc.relation.journalvolume | 22 | en_US |
dc.relation.journalissue | 20 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Institute of Food Safety and Health | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-9021-4616 | - |
crisitem.author.orcid | 0000-0003-3472-5512 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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