https://scholars.lib.ntu.edu.tw/handle/123456789/611059
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee, Chi Chan | en |
dc.contributor.author | Liang, Feng | en |
dc.contributor.author | Lee, I. Chi | en |
dc.contributor.author | Lu, Tsung Hao | en |
dc.contributor.author | Shan, Yu Yau | en |
dc.contributor.author | Jeng, Chih Fan | en |
dc.contributor.author | Zou, Yan Fang | en |
dc.contributor.author | HON-TSEN YU | en |
dc.contributor.author | SHIH-KUO CHEN | en |
dc.date.accessioned | 2022-05-14T23:36:02Z | - |
dc.date.available | 2022-05-14T23:36:02Z | - |
dc.date.issued | 2022-01-01 | en |
dc.identifier.issn | 1469221X | en |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/611059 | - |
dc.description.abstract | Gut microbiota are involved in many physiological functions such as metabolism, brain development, and neurodegenerative diseases. Many microbes in the digestive tract do not maintain a constant level of their relative abundance but show daily oscillations under normal conditions. Recent evidence indicates that chronic jetlag, constant darkness, or deletion of the circadian core gene can alter the composition of gut microbiota and dampen the daily oscillation of gut microbes. However, the neuronal circuit responsible for modulating gut microbiota remained unclear. Using genetic mouse models and 16s rRNA metagenomic analysis, we find that light-dark cycle information transmitted by the intrinsically photosensitive retinal ganglion cells (ipRGCs) is essential for daily oscillations of gut microbes under temporal restricted high-fat diet conditions. Furthermore, aberrant light exposure such as dim light at night (dLAN) can alter the composition, relative abundance, and daily oscillations of gut microbiota. Together, our results indicate that external light-dark cycle information can modulate gut microbiota in the direction from the brain to the gut via the sensory system. | en |
dc.publisher | John Wiley and Sons Inc | - |
dc.relation.ispartof | EMBO Reports | en |
dc.subject | dim light at night | gut microbiota | ipRGC | melanopsin | en |
dc.title | External light-dark cycle shapes gut microbiota through intrinsically photosensitive retinal ganglion cells | en |
dc.type | journal article | en |
dc.identifier.doi | 10.15252/embr.202052316 | en |
dc.identifier.scopus | 2-s2.0-85128731561 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85128731561 | en |
dc.contributor.orcid | 0000-0003-4157-9250 | en |
dc.contributor.orcid | 0000-0002-3646-8591 | en |
dc.contributor.orcid | 0000-0002-7921-1358 | en |
dc.relation.pages | Article number e52316 | - |
dc.relation.journalvolume | 23 | - |
dc.relation.journalissue | 6 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.orcid | 0000-0002-2911-0698 | - |
crisitem.author.orcid | 0000-0002-7921-1358 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 生命科學系 |
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