|Title:||The chromatin remodelling ATPase BRAHMA interacts with GATA-family transcription factor GNC to regulate flowering time in Arabidopsis||Authors:||Yang, Jie
Hung, Fu Yu
|Keywords:||BRAHMA (BRM) | CARBON METABOLISM INVOLVED) | chromatin remodelling | flowering time | GNC (GATA | NITRATE-INDUCIBLE | SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1)||Issue Date:||1-Jan-2022||Journal Volume:||73||Journal Issue:||3||Source:||Journal of Experimental Botany||Abstract:||
BRAHMA (BRM) is the ATPase of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodelling complex, which is indispensable for transcriptional inhibition and activation, associated with vegetative and reproductive development in Arabidopsis thaliana. Here, we show that BRM directly binds to the chromatin of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1), which integrates multiple flowering signals to regulate floral transition, leading to flowering. In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBON METABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression. Furthermore, BRM is recruited by GNC to directly bind to the chromatin of SOC1. The transcript level of SOC1 is elevated in brm-3, gnc, and brm-3/gnc mutants, which is associated with increased histone H3 lysine 4 tri-methylation (H3K4Me3) but decreased DNA methylation. Taken together, our results indicate that BRM associates with GNC to regulate SOC1 expression and flowering time.
|Appears in Collections:||植物科學研究所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.