https://scholars.lib.ntu.edu.tw/handle/123456789/616299
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Zhu, Lele | en_US |
dc.contributor.author | Zhou, Xiaofei | en_US |
dc.contributor.author | Gu, Meidi | en_US |
dc.contributor.author | Kim, Jiseong | en_US |
dc.contributor.author | Li, Yanchuan | en_US |
dc.contributor.author | Chun-Jung Ko | en_US |
dc.contributor.author | Xie, Xiaoping | en_US |
dc.contributor.author | Gao, Tianxiao | en_US |
dc.contributor.author | Cheng, Xuhong | en_US |
dc.contributor.author | Sun, Shao-Cong | en_US |
dc.date.accessioned | 2022-08-08T01:17:44Z | - |
dc.date.available | 2022-08-08T01:17:44Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.issn | 1476-4679 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/616299 | - |
dc.description.abstract | CD8+ T cells are central mediators of immune responses against infections and cancer. Here we identified Dapl1 as a crucial regulator of CD8+ T cell responses to cancer and infections. Dapl1 deficiency promotes the expansion of tumour-infiltrating effector memory-like CD8+ T cells and prevents their functional exhaustion, coupled with increased antitumour immunity and improved efficacy of adoptive T cell therapy. Dapl1 controls activation of NFATc2, a transcription factor required for the effector function of CD8+ T cells. Although NFATc2 mediates induction of the immune checkpoint receptor Tim3, competent NFATc2 activation prevents functional exhaustion of CD8+ T cells. Interestingly, exhausted CD8+ T cells display attenuated NFATc2 activation due to Tim3-mediated feedback inhibition; Dapl1 deletion rescues NFATc2 activation and thereby prevents dysfunction of exhausted CD8+ T cells in chronic infection and cancer. These findings establish Dapl1 as a crucial regulator of CD8+ T cell immunity and a potential target for cancer immunotherapy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | Nature cell biology | en_US |
dc.subject | TRANSCRIPTION FACTOR NFAT; SUBSETS; SIGNATURE | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41556-022-00942-8 | - |
dc.identifier.pmid | 35773432 | - |
dc.identifier.scopus | 2-s2.0-85133184599 | - |
dc.identifier.isi | WOS:000819264100002 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85133184599 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133184599&doi=10.1038%2fs41556-022-00942-8&partnerID=40&md5=f9fc8e09f842ffe717fd4dbbf182f1b0 | - |
dc.relation.journalvolume | 24 | en_US |
dc.relation.journalissue | 7 | en_US |
dc.relation.pageend | 1176 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0001-6565-7060 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 免疫學研究所 |
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