https://scholars.lib.ntu.edu.tw/handle/123456789/616615
標題: | Quantitative analysis of echogenicity for patients with thyroid nodules | 作者: | MING-HSUN WU CHIUNG-NIEN CHEN KUEN-YUAN CHEN MING-CHIH HO HAO-CHIH TAI Wang, Yu-Hsin Chen, A. ARGON CHEN KING-JEN CHANG |
公開日期: | 2016 | 出版社: | Nature Publishing Group | 卷: | 6 | 來源出版物: | Scientific Reports | 摘要: | Hypoechogenicity has been described qualitatively and is potentially subject to intra-and inter-observer variability. The aim of this study was to clarify whether quantitative echoic indexes (EIs) are useful for the detection of malignant thyroid nodules. Overall, 333 participants with 411 nodules were included in the final analysis. Quantification of echogenicity was performed using commercial software (AmCAD-UT; AmCad BioMed, Taiwan). The coordinates of three defined regions, the nodule, thyroid parenchyma, and strap muscle regions, were recorded in the database separately for subsequent analysis. And the results showed that ultrasound echogenicity (US-E), as assessed by clinicians, defined hypoechogenicity as an independent factor for malignancy. The EI, adjusted EI (EI N-T; EI N-M) and automatic EI (N-R)/R values between benign and malignant nodules were all significantly different, with lower values for malignant nodules. All of the EIs showed similar percentages of sensitivity and specificity and had better accuracies than US-E. In conclusion, the proposed quantitative EI seems more promising to constitute an important advancement than the conventional qualitative US-E in allowing for a more reliable distinction between benign and malignant thyroid nodules. © 2016 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992436564&doi=10.1038%2fsrep35632&partnerID=40&md5=b61c1dfe580db8fc00afb312a7868f21 https://scholars.lib.ntu.edu.tw/handle/123456789/616615 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep35632 |
顯示於: | 醫學系 |
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