https://scholars.lib.ntu.edu.tw/handle/123456789/619306
標題: | Global DNA methylation mediates the association between serum perfluorooctane sulfonate and carotid intima-media thickness in young and middle-aged Taiwanese populations | 作者: | Lin, Chien-Yu Lee, Hui-Ling CHING-WAY CHEN Wang, Chikang Sung, Fung-Chang TA-CHEN SU |
關鍵字: | 5mdC/dG; CIMT (carotid intima-media thickness); Global DNA methylation; PFAS (Perfluoroalkyl and polyfluoroalkyl substances); PFOS (perfluorooctane sulfonate) | 公開日期: | 八月-2022 | 卷: | 241 | 起(迄)頁: | 113782 | 來源出版物: | Ecotoxicology and environmental safety | 摘要: | Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals used in the manufacture of many everyday products. Previous reports have shown PFAS exposure may contribute to cardiovascular diseases (CVD). Recent studies have also identified a critical role for DNA methylation, a model of epigenetic regulation, in the pathogenesis of CVD. Additionally, PFAS has been shown to affect DNA methylation. Our previous study reported the positive association between serum perfluorooctane sulfonate (PFOS) levels and mean carotid intima-media thickness (CIMT), a biomarker of arteriosclerosis, in a cohort composed of adolescent and young adult Taiwanese. However, the contribution of DNA methylation in the mechanism of PFOS-induced arteriosclerosis has never been explored in previous literature. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/619306 | ISSN: | 01476513 | DOI: | 10.1016/j.ecoenv.2022.113782 |
顯示於: | 醫學系 |
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