https://scholars.lib.ntu.edu.tw/handle/123456789/619308
標題: | Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults | 作者: | CHING-WAY CHEN Tang, Shu-Yu Hwang, Jin-Shiang CHANG-CHUAN CHAN CHENG-CHIH HSU Lin, Chien-Yu TA-CHEN SU |
關鍵字: | di-(2-ethylhexyl) phthalate; health assessment; heart rate variability; plasticizers; young adults | 公開日期: | 12-十二月-2021 | 出版社: | MDPI | 卷: | 9 | 期: | 12 | 起(迄)頁: | 351 | 來源出版物: | Toxics | 摘要: | Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017-2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of DHEP. A continuous electrocardiogram was recorded to obtain a 5-min ECG. Time-domain and frequency-domain HRV analyses were performed. Multiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower triangular interpolation of NN interval histogram (TINN), very low frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio. DEHP is a potentially harmful and invisible chemical. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an adverse effect on autonomic balance in young adults in Taiwan. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/619308 | ISSN: | 2305-6304 | DOI: | 10.3390/toxics9120351 |
顯示於: | 醫學系 |
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