https://scholars.lib.ntu.edu.tw/handle/123456789/621217
Title: | Comparison of Osseointegration in Different Intravertebral Fixators | Authors: | Hsieh J.-Y JYH-HORNG WANG Chen P.-Q YI-YOU HUANG |
Keywords: | Vertebral compression fractures; Cementless; Modular spine blocks; Intravertebral fixation; Osseointegration; VERTEBRAL COMPRESSION FRACTURES; STABILIZATION; KYPHOPLASTY; IMPLANT; STRENGTH; CEMENT | Issue Date: | 2022 | Publisher: | SPRINGER HEIDELBERG | Journal Volume: | 42 | Journal Issue: | 2 | Start page/Pages: | 196 | Source: | JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING | Abstract: | Purpose: Percutaneous minimally invasive spinal surgery is performed to manage vertebral compression fractures. The novel modular spine block (MSB) is a spinal fixator designed to provide cementless intravertebral fixation. This study tested the rate of new bone formation in a porcine model following MSB fixation. Methods: A total of 24 MSBs were implanted in four pigs that served as porcine animal models: solid MSB designated as MSB-0, perforated MSB as MSB-1, hollow MSB as MSB-2, porous 3D-printed MSB as MSB-3. Commercially available intravertebral expandable pillars (IVEP) were also implanted, to serve as a comparison with the MSBs. All pigs underwent X-ray imaging, computed tomography (CT), micro-CT, and histomorphometry. The bone volume fraction (bone volume/tissue volume, BV/TV), bone surface density (bone surface area/tissue volume, BS/TV), trabecular bone thickness (TBT), trabecular bone number (TBN), and trabecular bone separation (TBS) were evaluated. Results: All fixators were securely implanted without any major complications. Adequate alignment of the implants was confirmed radiologically. Marked bone growth was observed on micro-CT and histomorphometry. The average results of BV/TV, BS/TV, TBT, and TBN were the highest in the MSB-2 cases, whereas the values of TBS were the lowest. No statistically significant differences were found between the various intravertebral fixators used. Conclusions: These findings suggest that MSBs have a similar positive effect on osseointegration as other commercially available cementless intravertebral device. Since these data were obtained from porcine models, further clinical research is required to confirm the reproducibility of these data in humans. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/621217 | ISSN: | 1609-0985 | DOI: | 10.1007/s40846-022-00698-4 |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.