https://scholars.lib.ntu.edu.tw/handle/123456789/623394
標題: | Dopamine-Modified Alginate Hydrogel with Effectiveness and Safety for Preoperative Localization of Lung Nodules | 作者: | Ji, You-Ren Young, Tai-Horng Tsai, Ting-Yu JIN-SHING CHEN KE-CHENG CHEN |
公開日期: | 九月-2021 | 出版社: | American Chemical Society | 卷: | 7 | 期: | 9 | 起(迄)頁: | 4637-4644 | 來源出版物: | ACS Biomaterials Science and Engineering | 摘要: | It is important to mark an early lung tumor manifested with small nodules during computed tomography-guided and minimally invasive surgery. The aim of this study is to develop an injectable hydrogel for clinical lung nodule localization. Dopamine, a typical catechol-containing compound, was used to modify alginate for better gel formation and performance needed for localization application. Through the addition of an adequate oxidant and catalase, the catechol-conjugated alginate (C-ALG) hydrogel showed rapid gelation for less than 5 min, similar mechanical properties to lung tissue, slight swelling degree, good cell compatibility, and enough tissue adhesion for localization around the lung tissue. In addition, the C-ALG hydrogel increased the bursting pressure of lung tissue up to 266 ± 15-385 ± 13 mm-H2O that could prevent hydrogel rupture and migration during localizing surgery, suggesting the injectable hydrogel with effectiveness and safety for clinical applications. © 2021 American Chemical Society |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114344256&doi=10.1021%2facsbiomaterials.1c00512&partnerID=40&md5=a6a9c7fd10c1390142bfa792895aabac https://scholars.lib.ntu.edu.tw/handle/123456789/623394 |
ISSN: | 2373-9878 | DOI: | 10.1021/acsbiomaterials.1c00512 |
顯示於: | 醫學系 |
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