https://scholars.lib.ntu.edu.tw/handle/123456789/624355
DC Field | Value | Language |
---|---|---|
dc.contributor.author | FAN-CHI CHANG | en_US |
dc.contributor.author | Liu, Chia-Hao | en_US |
dc.contributor.author | Luo, An-Jie | en_US |
dc.contributor.author | TAO-MIN HUANG | en_US |
dc.contributor.author | Tsai, Ming-Hsuan | en_US |
dc.contributor.author | Chen, Yu-Jhen | en_US |
dc.contributor.author | CHUN-FU LAI | en_US |
dc.contributor.author | CHIH-KANG CHIANG | en_US |
dc.contributor.author | Lin, Tzu-Hung | en_US |
dc.contributor.author | WEN-CHIH CHIANG | en_US |
dc.contributor.author | YUNG-MING CHEN | en_US |
dc.contributor.author | Chu, Tzong-Shinn | en_US |
dc.contributor.author | SHUEI-LIONG LIN | en_US |
dc.date.accessioned | 2022-11-01T08:45:59Z | - |
dc.date.available | 2022-11-01T08:45:59Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 00852538 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/624355 | - |
dc.description.abstract | Plasma levels of angiopoietin-2 are increased in patients with chronic kidney disease (CKD). Moreover, mouse models of progressive kidney disease also demonstrate increased angiopoietin-2 in both plasmas and kidneys. The role of dysregulated angiopoietins in the progression of kidney disease has not been thoroughly investigated. Here, we found in a cohort of 319 patients with CKD that plasma angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratios were positively associated with the development of kidney failure. In mice with progressive kidney disease induced by either ureteral obstruction or ischemia-reperfusion injury, overexpression of human angiopoietin-1 in the kidney tubules not only reduced macrophage infiltration in the initial stage post-injury but also attenuated endothelial cell apoptosis, microvascular rarefaction, and fibrosis in the advanced disease stage. Notably, angiopoietin-1 attenuated chemokine C-C motif ligand 2 (CCL2) expression in the endothelial cells of the fibrosing kidneys, and these protective effects led to attenuation of functional impairment. Mechanistically, angiopoietin-1 reduced CCL2-activated macrophage migration and protected endothelial cells against cell apoptosis induced by angiopoietin-2 and Wnt ligands. Based on this, we applied L1-10, an angiopoietin-2 inhibitor, to the mouse models of progressive kidney disease and found inhibitory effects on macrophage infiltration, microvascular rarefaction, and fibrosis. Thus, we defined the detrimental impact of increased angiopoietin-2 on kidney survival of patients with CKD which appears highlighted by angiopoietin-2 induced endothelial CCL2-activated macrophage infiltration and endothelial cell apoptosis in their kidneys undergoing fibrosis. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Kidney international | en_US |
dc.subject | chemokine; chronic kidney disease; endothelium; fibrosis; macrophage | en_US |
dc.title | Angiopoietin-2 inhibition attenuates kidney fibrosis by hindering chemokine C-C motif ligand 2 expression and apoptosis of endothelial cells | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1016/j.kint.2022.06.026 | - |
dc.identifier.pmid | 35934136 | - |
dc.identifier.scopus | 2-s2.0-85136588511 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/620490 | - |
dc.relation.journalvolume | 102 | en_US |
dc.relation.journalissue | 4 | en_US |
dc.relation.pageend | 797 | en_US |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Institute of Food Safety and Health | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Geriatrics and Gerontology-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.dept | Physiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.orcid | 0000-0002-1821-1952 | - |
crisitem.author.orcid | 0000-0002-9387-0798 | - |
crisitem.author.orcid | 0000-0003-2109-1522 | - |
crisitem.author.orcid | 0000-0001-9021-4616 | - |
crisitem.author.orcid | 0000-0002-8844-0988 | - |
crisitem.author.orcid | 0000-0002-9241-1258 | - |
crisitem.author.orcid | 0000-0002-1041-5571 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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