https://scholars.lib.ntu.edu.tw/handle/123456789/624721
標題: | Multi-Bevel Needle Design Enabling Accurate Insertion in Biopsy for Cancer Diagnosis | 作者: | Li A.D.R Liu Y Plott J Chen L Montgomery J.S Shih A. DIAN-RU LI |
關鍵字: | Lagrangian analysis; Needle deflection; needle insertion modeling; smoothed particle Galerkin method; tissue deformation; tissue sampling | 公開日期: | 2021 | 卷: | 68 | 期: | 5 | 起(迄)頁: | 1477-1486 | 來源出版物: | IEEE Transactions on Biomedical Engineering | 摘要: | Objective: To obtain definitive cancer diagnosis for suspicious lesions, accurate needle deployment and adequate tissue sampling in needle biopsy are essential. However, the single-bevel needles in current biopsy devices often induce deflection during insertion, potentially causing lesion missampling/undersampling and cancer misdiagnosis. This study aims to reveal the biopsy needle design criteria enabling both low deflection and adequate tissue sampling. Methods: A novel model capable of predicting needle deflection and tissue deformation was first established to understand needle-Tissue interaction with different needle tip geometries. Experiments of needle deflection and ex-vivo tissue biopsy were conducted for model validation. Results: The developed model showed a reasonably good prediction on the correlation of needle tip type vs.The resultant needle deflection and tissue sampling length. A new multi-bevel needle with the tissue separation point below the needle groove face has demonstrated to be an effective design with an 87% reduction in deflection magnitude and equivalently long tissue sampling length compared to the current single-bevel needle. Conclusion: This study has revealed two critical design criteria for biopsy needles: 1) multiple bevel faces at the needle tip can generate forces to balance bending moments during insertion to enable a low needle deflection and 2) the tissue separation point should be below the needle groove face to ensure long tissue sampling length. Significance: The developed methodologies and findings in this study serve as proof-of-concept and can be utilized to investigate various biopsy procedures to improve cancer diagnostic accuracy as well as other procedures requiring accurate needle insertion. © 1964-2012 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100484967&doi=10.1109%2fTBME.2021.3054922&partnerID=40&md5=5dea9a9586dea4677f6f9be0ce969b7d https://scholars.lib.ntu.edu.tw/handle/123456789/624721 |
ISSN: | 00189294 | DOI: | 10.1109/TBME.2021.3054922 | SDG/關鍵字: | Biopsy; Deflection (structures); Diseases; Tissue; Cancer diagnosis; Cancer diagnostics; Deflection magnitude; Needle deflection; Needle-tissue interaction; Proof of concept; Tissue deformations; Tissue separations; Needles; Article; breast tissue; cancer diagnosis; equipment design; ex vivo study; geometry; human; human tissue; sampling; tumor biopsy; validation study; equipment design; needle; needle biopsy; neoplasm; Biopsy, Needle; Equipment Design; Needles; Neoplasms |
顯示於: | 機械工程學系 |
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