https://scholars.lib.ntu.edu.tw/handle/123456789/625208
標題: | Novel Application of Photo-Crosslinked Urocanic-Acid-Modified Chitosan in Corneal Wounds | 作者: | Lee A.-L Hsieh H.-Y Chen Y.-Y Tsai L.-H Wey S.-L Chen D.-S YI-JANE CHEN TAI-HORNG YOUNG |
關鍵字: | bioadhesive; hydrogel; ophthalmic injury; photochemical; tissue glue; wound healing | 公開日期: | 2022 | 來源出版物: | ACS Biomaterials Science and Engineering | 摘要: | In the last few years, the use of tissue adhesives in corneal perforation has gained immense popularity in clinical practices. The present study aimed to devise a new application of urocanic-acid-modified chitosan (CS) with methylene blue (MB) as a photosensitizer for the development of a photo-crosslinked tissue adhesive. In particular, the curing time was controlled with the aid of a 650 nm red diode. Under the same irradiation condition, the mechanical properties were tuned using the photosensitizer at different concentrations. In vitro tests revealed that the gel was ductile and biocompatible. The application of the gel to a perforated cornea model stopped the leakage of aqueous humor, immediately after the gel was photo-crosslinked. The blue appearance of the gel provided high precision when applied to corneal wounds. Importantly, the crosslinked gel became transparent within 24 h, owing to the dissipation of MB from tears, and the gel spontaneously sloughed off without artificial removal. Altogether, the study reported the development of a novel photo-crosslinkable urocanic-acid-modified CS gel that exhibited significant potential to be utilized in the healing of corneal perforation. © 2022 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129107153&doi=10.1021%2facsbiomaterials.2c00050&partnerID=40&md5=b059e81e458600e7418631b1b935de21 https://scholars.lib.ntu.edu.tw/handle/123456789/625208 |
ISSN: | 23739878 | DOI: | 10.1021/acsbiomaterials.2c00050 | SDG/關鍵字: | Adhesives; Aromatic compounds; Biocompatibility; Biomechanics; Chitosan; Bio adhesives; Crosslinked; Methylene Blue; Modified chitosan; Ophthalmic injury; Photochemicals; Tissue adhesives; Tissue glue; Urocanic acid; Wound healing; Photosensitizers; chitosan; photosensitizing agent; urocanic acid; cornea perforation; human; hydrogel; Chitosan; Corneal Perforation; Humans; Hydrogels; Photosensitizing Agents; Urocanic Acid |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。