https://scholars.lib.ntu.edu.tw/handle/123456789/626457
Title: | A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges | Authors: | Yang, Li-Xing Liu, Yu-Cheng Cho, Chang-Hui Chen, Yi-Rou Yang, Chan-Shan Lu, Yin-Lin Zhang, Zhiming Tsai, Yi-Tseng Chin, Yu-Cheng JIASHING YU Pan, Hsiu-Min Jiang, Wei-Rou Chia, Zi-Chun Huang, Wei-Shiang Chiu, Yu-Lin Sun, Chun-Kai Huang, Yu-Ting Chen, Li-Ming KEN-TSUNG WONG Huang, Han-Min Chen, Chih-Hsin Chang, Yuan Jay Huang, Chih-Chia Liu, Tzu-Ming |
Keywords: | Fluorescence imaging; Multiphoton microscopy; Near-infrared red; Optoelectronic material; Photodynamic therapy; Polymer; Theranostic | Issue Date: | 6-Jul-2022 | Publisher: | BMC | Journal Volume: | 20 | Journal Issue: | 1 | Source: | Journal of nanobiotechnology | Abstract: | The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1-1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7-50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1-3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626457 | ISSN: | 1477-3155 | DOI: | 10.1186/s12951-022-01515-5 |
Appears in Collections: | 化學系 |
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