https://scholars.lib.ntu.edu.tw/handle/123456789/626471
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee, Chia Ying | en_US |
dc.contributor.author | CHI-TING SU | en_US |
dc.contributor.author | Tsai, Tsuimin | en_US |
dc.contributor.author | Hsieh, Chien-Ming | en_US |
dc.contributor.author | KUAN-YU HUNG | en_US |
dc.contributor.author | Huang, Jeng-Wen | en_US |
dc.contributor.author | CHIN-TIN CHEN | en_US |
dc.date.accessioned | 2022-12-15T03:51:11Z | - |
dc.date.available | 2022-12-15T03:51:11Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 00223549 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/626471 | - |
dc.description.abstract | Liposomes have been used to improve therapeutic efficacy of drugs by increasing their bioavailability and altering biodistribution. The loading capacity of small molecules in liposomes remains a critical issue. Besides, the manufacturing process of liposomes requires multi-step procedures which hinders the clinical development. In this study, we developed a promising lipid-based nanocarriers (LN) delivery system for hydrophilic charged compounds using doxycycline (Doxy) as a model drug. This Doxy-loaded lipid nanocarrier (LN-Doxy) was fabricated by microfluidic technology. Design of experiments (DoE) was constructed to outline the interactions among the critical attributes of formulation, the parameters of microfluidic systems and excipient compositions. Response surface methodology (RSM) was furthered used for the optimization of LN-Doxy formulation. The LN-Doxy developed in this study showed high drug to lipid ratio and uniform distribution of particle size. Compared to Doxy solution, this LN-Doxy has reduced in vitro cellular toxicity and significant therapeutic efficacy which was verified in a peritonitis animal model. These results show the feasibility of using microfluidic technology combined with QbD approach to develop the LN formulation with high loading efficiency for ionizable hydrophilic drugs. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of pharmaceutical sciences | en_US |
dc.subject | Design of experiment; Doxycycline; Lipid-based nanocarrier; Microfluidics | en_US |
dc.title | Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.xphs.2022.09.023 | - |
dc.identifier.pmid | 36170906 | - |
dc.identifier.scopus | 2-s2.0-85140711425 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85140711425 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Biochemical Science and Technology | - |
crisitem.author.orcid | 0000-0002-2926-3950 | - |
crisitem.author.orcid | 0000-0003-3472-5512 | - |
crisitem.author.orcid | 0000-0002-7439-8774 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 生化科技學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。